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Kif3a - kinesin family member 3A Gene

Also Known as Kif3; Kifl; Kns3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16568

Summary

Enables intraciliary transport particle B binding activity and microtubule binding activity. Involved in centriole-centriole cohesion and microtubule anchoring at centrosome. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and plasma membrane bounded cell projection organization. Located in centriole; motile cilium; and photoreceptor connecting cilium. Part of Kinesin II complex. Is expressed in several structures, including gonad; liver; neural tube; node; and spleen. Used to study dysostosis and polycystic kidney disease. Orthologous to human KIF3A (Kinesin family member 3A). [provided by Alliance of Genome Resources, Apr 2022]

Kif3a Products (3)

mRNA	Protein	Name
NM_001290805.1	NP_001277734.1	kinesin-like protein KIF3A isoform 2
NM_001290806.1	NP_001277735.1	kinesin-like protein KIF3A isoform 3
NM_008443.4	NP_032469.2	kinesin-like protein KIF3A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables intraciliary transport particle B binding	IDA IDA: Inferred from direct assay	12821668	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	17360631	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12821668	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in alpha-tubulin acetylation	IMP IMP: Inferred from mutant phenotype	27793670	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	10220415	MGI
involved in anterograde dendritic transport	EXP EXP: Inferred from Experiment	26335646	MGI
involved in anterograde dendritic transport	IDA IDA: Inferred from direct assay	26335646	MGI
involved in anterograde dendritic transport	IEP IEP: Inferred from expression pattern	26335646	MGI
involved in anterograde dendritic transport	IMP IMP: Inferred from mutant phenotype	26335646	MGI
involved in anterograde dendritic transport of neurotransmitter receptor complex	IDA IDA: Inferred from direct assay	31746486	MGI
involved in anterograde dendritic transport of neurotransmitter receptor complex	IMP IMP: Inferred from mutant phenotype	31746486	MGI
involved in centriole-centriole cohesion	IMP IMP: Inferred from mutant phenotype	23386061	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	10220415	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of or within cilium movement	IMP IMP: Inferred from mutant phenotype	29891944	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	18297065	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	10220415	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	18590716	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	18590716	MGI
involved in dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within epidermal stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	21429982	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	28291836	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	18729223	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	10330409	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	19286674	MGI
acts upstream of or within inner ear receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	18066062	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	15067314	MGI
involved in microtubule anchoring at centrosome	IMP IMP: Inferred from mutant phenotype	23386061	MGI
acts upstream of or within motile cilium assembly	IMP IMP: Inferred from mutant phenotype	10330409	MGI
acts upstream of or within neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	18297065	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	10330409	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	18297065	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18297065	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	27793670	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	23386061	MGI
located in cilium	IDA IDA: Inferred from direct assay	17825299	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31746486	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	31746486	MGI
part of kinesin II complex	IDA IDA: Inferred from direct assay	19384852	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	10330409	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	17360631	MGI
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	19208653	MGI
is active in postsynapse	EXP EXP: Inferred from Experiment	26335646	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	26335646	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	26335646	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	26335646	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
kinesin-like protein KIF3A	N-4 kinesin kinesin-II subunit microtubule plus end-directed kinesin motor 3A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07285	KIF3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22595	Kif3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29112	Kif3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif3a	NCBI	NCBI:11127