Kif5b - kinesin family member 5B Gene

Also Known as Khc; Khcs; Kns1; Ukhc

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16573

Summary

Predicted to enable several functions, including ATP hydrolysis activity; JUN kinase binding activity; and microtubule lateral binding activity. Involved in positive regulation of GABAergic synaptic transmission and stress granule disassembly. Acts upstream of or within cellular response to interferon-gamma; cytoplasm organization; and plus-end-directed vesicle transport along microtubule. Located in ciliary rootlet; neuron projection; and phagocytic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human KIF5B (Kinesin family member 5B). [provided by Alliance of Genome Resources, Apr 2022]

Kif5b Products (1)

mRNA	Protein	Name
NM_008448.3	NP_032474.2	kinesin-1 heavy chain

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9624122	MGI
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	29276473	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
acts upstream of or within cytoplasm organization	IMP IMP: Inferred from mutant phenotype	9657148	MGI
acts upstream of or within mitochondrion transport along microtubule	IMP IMP: Inferred from mutant phenotype	34048705	MGI
acts upstream of or within mitocytosis	IMP IMP: Inferred from mutant phenotype	34048705	MGI
acts upstream of or within plus-end-directed vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	17360972	MGI
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	20152113	MGI
involved in regulation of modification of synapse structure, modulating synaptic transmission	IDA IDA: Inferred from direct assay	31961321	MGI
involved in regulation of modification of synapse structure, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	31961321	MGI
involved in stress granule disassembly	IMP IMP: Inferred from mutant phenotype	19825938	MGI
acts upstream of or within vesicle transport along microtubule	IGI IGI: Inferred from genetic interaction	17360972	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary rootlet	IDA IDA: Inferred from direct assay	16018997	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16018997	MGI
located in endocytic vesicle	IDA IDA: Inferred from direct assay	17360972	MGI
located in membrane-bounded organelle	IDA IDA: Inferred from direct assay	12805290	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	34048705	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	16301330	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	31961321	MGI
is active in postsynaptic cytosol	IEP IEP: Inferred from expression pattern	31961321	MGI
is active in postsynaptic cytosol	IMP IMP: Inferred from mutant phenotype	31961321	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
kinesin-1 heavy chain	conventional kinesin heavy chain kinesin heavy chain member 5B, ubiquitous ubiquitous kinesin heavy chain

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-178061	APS03118	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-146710	RET-IN-16	Inhibitor	/	Unkown
HY-170852	QZ2135	Degrader	/	Unkown
HY-170855A	YW-N-7 TFA	Degrader	/	Unkown
HY-178964	PROTAC RET Degrader 1	Degrader	/	Unkown
HY-RS07290	KIF5B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18287	Kif5b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24765	Kif5b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif5b	NCBI	NCBI:3799