Mafb - v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) Gene

Also Known as kr; Krml; Krml1; Kreisler

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16658

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in abducens nerve formation; negative regulation of osteoclast differentiation; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and respiratory gaseous exchange by respiratory system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Used to study Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]

Mafb Products (1)

mRNA Protein Name
NM_010658.3 NP_034788.1 transcription factor MafB

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12701106 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
12701106 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
12701106 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12798298 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11823429 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
19164599 MGI
involved in abducens nerve formation IMP
IMP: Inferred from mutant phenotype
27181683 MGI
acts upstream of or within brain segmentation IMP
IMP: Inferred from mutant phenotype
7925021 MGI
involved in cornified envelope assembly IMP
IMP: Inferred from mutant phenotype
27208706 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
27208706 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
16325169 MGI
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
27208706 MGI
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
19440205 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11823429 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12798298 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12701106 MGI
involved in protein processing IMP
IMP: Inferred from mutant phenotype
27208706 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12701106 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
14513037 MGI
acts upstream of or within rhombomere 5 development IMP
IMP: Inferred from mutant phenotype
7925021 MGI
acts upstream of or within rhombomere 6 development IMP
IMP: Inferred from mutant phenotype
7925021 MGI
acts upstream of or within segment specification IMP
IMP: Inferred from mutant phenotype
12701106 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
19164599 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12917329 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12798298 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor MafB

  • Kreisler (maf-related) leucine zipper protein

  • V-maf musculoaponeurotic fibrosarcoma oncogene homolog B

  • maf-B

  • segmentation protein Kr

  • transcription factor Maf-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07959 MAFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19144 Mafb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25635 Mafb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mafb NCBI NCBI:9935