Krt2 - keratin 2 Gene

Also Known as Krt2e; Krt2-2; Krt2-17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16681

Summary

Enables cytoskeletal protein binding activity. A structural constituent of skin epidermis. Involved in positive regulation of epidermis development. Acts upstream of or within intermediate filament organization and keratinocyte development. Located in keratin filament. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; neural retina; and vagina. Used to study bullous congenital ichthyosiform erythroderma. Human ortholog(s) of this gene implicated in bullous congenital ichthyosiform erythroderma and ichthyosis. Orthologous to human KRT2 (keratin 2). [provided by Alliance of Genome Resources, Apr 2022]

Krt2 Products (1)

mRNA Protein Name
NM_010668.2 NP_034798.2 keratin, type II cytoskeletal 2 epidermal

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal protein binding IMP
IMP: Inferred from mutant phenotype
24751727 MGI
enables structural constituent of skin epidermis IMP
IMP: Inferred from mutant phenotype
24751727 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
24751727 MGI
acts upstream of or within intermediate filament organization IMP
IMP: Inferred from mutant phenotype
24751727 MGI
acts upstream of or within keratinocyte development IMP
IMP: Inferred from mutant phenotype
24751727 MGI
involved in positive regulation of epidermis development IMP
IMP: Inferred from mutant phenotype
26603179 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24751727 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
24751727 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 2 epidermal

  • CK-2e

  • K2e

  • cytokeratin-2e

  • epithelial keratin-2e

  • keratin 2 epidermis

  • keratin complex 2, basic, gene 17

  • keratin complex 2, gene 17

  • keratin-2e

  • type-II keratin Kb2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07443 KRT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22215 Krt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt2 NCBI NCBI:3849