DEFA5 - defensin alpha 5 Gene

Homo sapiens

Also known as DEF5; HD-5

Gene ID: 1670 | Gene type: protein coding

About DEFA5

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:7,055,304-7,056,739 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 200 orthologues and 5 paralogues. Restricted expression toward small intestine (RPKM 5886.0).

Summary

Defensins are a family of antimicrobial and cytotoxic Peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]

DEFA5 Products(1)

mRNA	Protein	Name
NM_021010.3	NP_066290.1	defensin alpha 5 preproprotein

DEFA5 Protein Structure

Defensin_propep

Defensin_1

0
94 a.a.

Protein Preferred Names

Protein Names

defensin alpha 5

HD5(20-94)

Related Diseases

Diseases

Alias

Urethritis

Nonspecific Urethritis	Non-Gonococcal Urethritis
Nongonococcal Urethritis

Microsporidiosis

Infection By Microspora	Microsporidiasis
Infection By Microsporea	Infection By Microsporida
Intestinal Microsporidiosis	Microsporidia Infection
Infection By Microsporidia

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Inflammatory Bowel Disease 2

IBD2

Crohn'S Colitis

Crohn Disease

Pyelonephritis

Colitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Febrile Seizures, Familial, 6

FEB6	Familial Febrile Seizures 6
Convulsions, Familial Febrile, 6	Familial Febrile Convulsions 6
Febrile Convulsions, Familial, 6

Chronic Pyelonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03676	DEFA5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DEFA5	RGD	RGD:727951

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