L1cam - L1 cell adhesion molecule Gene

Also Known as L1; CD171; NCAM-L1; N-CAM-L1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16728

Summary

Enables several functions, including identical protein binding activity; Integrin binding activity; and sialic acid binding activity. Acts upstream of or within several processes, including cell-cell adhesion mediated by integrin; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhesion molecules. Located in external side of plasma membrane; presynaptic membrane; and terminal bouton. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

L1cam Products (2)

mRNA Protein Name
NM_001374694.1 NP_001361623.1 neural cell adhesion molecule L1 isoform 2 precursor
NM_008478.3 NP_032504.3 neural cell adhesion molecule L1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
8557754 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
18550718 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
8557754 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7613634 MGI
enables sialic acid binding IDA
IDA: Inferred from direct assay
11283023 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
18650339 MGI
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
18550718 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
12533613 MGI
acts upstream of calcium-mediated signaling IDA
IDA: Inferred from direct assay
7613634 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
7613634 MGI
acts upstream of or within cell-cell adhesion mediated by integrin IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
8557754 MGI
acts upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules IMP
IMP: Inferred from mutant phenotype
7669058 MGI
acts upstream of or within homotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
7613634 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8117278 MGI
involved in maintenance of synapse structure IDA
IDA: Inferred from direct assay
30846310 MGI
involved in maintenance of synapse structure IMP
IMP: Inferred from mutant phenotype
30846310 MGI
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
11283023 MGI
acts upstream of or within neuron projection development IMP
IMP: Inferred from mutant phenotype
11283023 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
7613634 MGI
acts upstream of or within positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
7669058 MGI
involved in regulation of synapse assembly IDA
IDA: Inferred from direct assay
30846310 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
30846310 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
30846310 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
30846310 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
16537644 MGI
located in cell surface IDA
IDA: Inferred from direct assay
12514225 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7613634 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16537644 MGI
located in membrane IDA
IDA: Inferred from direct assay
11283023 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
34380733 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
16537644 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
16537644 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
16537644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neural cell adhesion molecule L1

Recombinant L1cam Proteins

Cat. No. Product Name Accession Purity
HY-P77732 L1CAM Protein, Mouse (HEK293, His) P11627 (I20-E1123) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184514 TPA(bi(Tos))-γ-Glu(PEG23)-Glu-Val-Cit-PAB-PNU-159682 / Unkown
HY-184522 TPA(bi(Tos))-γ-Glu(PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682 / Unkown
HY-RS07481 L1CAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18070 L1cam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24545 L1cam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992253 Anti-L1-CAM Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens L1cam NCBI NCBI:3897