Lama2 - laminin, alpha 2 Gene

Also Known as dy; mer; merosin; mKIAA4087; 5830440B04

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16773

Summary

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon guidance and positive regulation of cholinergic synaptic transmission. Located in several cellular components, including neuromuscular junction; sarcolemma; and synaptic cleft. Is expressed in several structures, including alimentary system; basement membrane; metanephros; musculature; and skin. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Lama2 Products (1)

mRNA Protein Name
NM_008481.2 NP_032507.2 laminin subunit alpha-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24722207 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IGI
IGI: Inferred from genetic interaction
19295126 MGI
acts upstream of or within positive regulation of synaptic transmission, cholinergic IMP
IMP: Inferred from mutant phenotype
8568931 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
9264260 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
9396756 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
9524190 MGI
is active in synaptic cleft IDA
IDA: Inferred from direct assay
9396756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

laminin subunit alpha-2

  • dystrophia muscularis

  • laminin M chain

  • laminin-12 subunit alpha

  • laminin-2 subunit alpha

  • laminin-4 subunit alpha

  • merosin heavy chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07498 LAMA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20977 Lama2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27494 Lama2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lama2 NCBI NCBI:3908