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Laptm5 - lysosomal-associated protein transmembrane 5 Gene

Also Known as E3; Stra13

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16792

Summary

Enables enzyme binding activity and protein sequestering activity. Involved in several processes, including lysosomal transport; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Located in lysosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human LAPTM5 (lysosomal protein transmembrane 5). [provided by Alliance of Genome Resources, Apr 2022]

Laptm5 Products (1)

mRNA	Protein	Name
NM_010686.4	NP_034816.1	lysosomal-associated transmembrane protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	22733818	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18619870	MGI
enables protein sequestering activity	IMP IMP: Inferred from mutant phenotype	18619870	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi to lysosome transport	IDA IDA: Inferred from direct assay	24638062	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	31545469	MGI
involved in negative regulation of B cell activation	IMP IMP: Inferred from mutant phenotype	20519653	MGI
involved in negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	18619870	MGI
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18619870	MGI
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	18619870	MGI
involved in negative regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	18619870	MGI
involved in negative regulation of pre-B cell receptor expression	IMP IMP: Inferred from mutant phenotype	22949502	MGI
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18619870	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	22949502	MGI
involved in positive regulation of receptor catabolic process	IMP IMP: Inferred from mutant phenotype	20519653	MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22733818	MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24638062	MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	18619870	MGI
involved in protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	22949502	MGI
involved in protein targeting to lysosome	IDA IDA: Inferred from direct assay	18619870	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in lysosome	IDA IDA: Inferred from direct assay	18619870	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lysosomal-associated transmembrane protein 5	lysosomal-associated multitransmembrane protein 5 retinoic acid-inducible E3 protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07523	LAPTM5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19785	Laptm5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26282	Laptm5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Laptm5	NCBI	NCBI:7805