Lhcgr - luteinizing hormone/choriogonadotropin receptor Gene

Also Known as Lhr; LH-R; LSH-R; LH/CG-R; Gpcr19-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16867

Summary

Enables choriogonadotropin hormone binding activity and choriogonadotropin hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of Adenylate Cyclase activity; and positive regulation of inositol trisphosphate biosynthetic process. Acts upstream of or within several processes, including development of secondary male sexual characteristics; regulation of steroid hormone biosynthetic process; and reproductive structure development. Is integral component of plasma membrane. Is expressed in early conceptus; medulla oblongata; medulla oblongata basal plate ventricular layer; oocyte; and testis. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lhcgr Products (2)

mRNA Protein Name
NM_001364898.1 NP_001351827.1 lutropin-choriogonadotropic hormone receptor isoform 2 precursor
NM_013582.3 NP_038610.1 lutropin-choriogonadotropic hormone receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables choriogonadotropin hormone binding IDA
IDA: Inferred from direct assay
10493819 MGI
enables choriogonadotropin hormone receptor activity IDA
IDA: Inferred from direct assay
10493819 MGI
enables choriogonadotropin hormone receptor activity IMP
IMP: Inferred from mutant phenotype
11145748 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
10493819 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10493819 MGI
involved in cellular response to gonadotropin stimulus IDA
IDA: Inferred from direct assay
10493819 MGI
acts upstream of or within development of secondary male sexual characteristics IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within ovulation cycle process IMP
IMP: Inferred from mutant phenotype
11145748 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
10493819 MGI
involved in positive regulation of inositol trisphosphate biosynthetic process IDA
IDA: Inferred from direct assay
10493819 MGI
acts upstream of or within regulation of steroid hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11145748 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
11145748 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
10493819 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lutropin-choriogonadotropic hormone receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150210 FSHR agonist 1 Agonist 99.45% Unkown
HY-100271 Org41841 Agonist 99.77% Unkown
HY-RS07624 LHCGR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10594 Myr-Arf1(2–17) / Unkown
HY-RS17915 Lhcgr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24384 Lhcgr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lhcgr NCBI NCBI:3973