Lig3 - ligase III, DNA, ATP-dependent Gene

Also Known as D11Wsu78e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16882

Summary

Predicted to enable DNA Ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining and mitochondrion organization. Acts upstream of or within double-strand break repair via nonhomologous end joining; mitochondrial DNA repair; and negative regulation of DNA recombination. Located in synaptonemal complex. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human LIG3 (DNA Ligase 3). [provided by Alliance of Genome Resources, Apr 2022]

Lig3 Products (14)

mRNA Protein Name
NM_001291245.2 NP_001278174.1 DNA ligase 3 isoform a
NM_001291246.2 NP_001278175.1 DNA ligase 3 isoform b
NM_001291247.2 NP_001278176.1 DNA ligase 3 isoform b
NM_001403856.1 NP_001390785.1 DNA ligase 3 isoform a
NM_001403857.1 NP_001390786.1 DNA ligase 3 isoform a
NM_001403858.1 NP_001390787.1 DNA ligase 3 isoform b
NM_001403859.1 NP_001390788.1 DNA ligase 3 isoform c
NM_001403860.1 NP_001390789.1 DNA ligase 3 isoform d
NM_001403861.1 NP_001390790.1 DNA ligase 3 isoform e
NM_001403862.1 NP_001390791.1 DNA ligase 3 isoform f
NM_001403863.1 NP_001390792.1 DNA ligase 3 isoform g
NM_001403864.1 NP_001390793.1 DNA ligase 3 isoform h
NM_001403865.1 NP_001390794.1 DNA ligase 3 isoform i
NM_010716.4 NP_034846.2 DNA ligase 3 isoform a

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in double-strand break repair via alternative nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
21655080 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
21655080 MGI
acts upstream of or within mitochondrial DNA repair IMP
IMP: Inferred from mutant phenotype
21390131 MGI
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
21390131 MGI
acts upstream of or within negative regulation of DNA recombination IMP
IMP: Inferred from mutant phenotype
16648486 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
9001252 MGI
located in synaptonemal complex IDA
IDA: Inferred from direct assay
9001252 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA ligase 3

  • DNA ligase (ATP) 3

  • DNA ligase III

  • polydeoxyribonucleotide synthase [ATP] 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07643 LIG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07789 LRIG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22220 Lig3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28742 Lig3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991208 Flt-3L-Ig (hum/hum) 98% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lig3 NCBI NCBI:3980