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Lmx1b - LIM homeobox transcription factor 1 beta Gene

Also Known as Icst; LMX1.1; LMX1.2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16917

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including memory; olfactory behavior; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including Collagen fibril organization; nervous system development; and trabecular meshwork development. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; hemolymphoid system; limb; and limb bud. Used to study nail-patella syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta). [provided by Alliance of Genome Resources, Apr 2022]

Lmx1b Products (1)

mRNA	Protein	Name
NM_010725.3	NP_034855.3	LIM homeobox transcription factor 1-beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19951692	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19951692	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23308148	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	10660670	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	17166916	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	17151281	MGI
acts upstream of or within cerebellum morphogenesis	IMP IMP: Inferred from mutant phenotype	17166916	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	10660670	MGI
involved in dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	19951692	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	21752929	MGI
involved in dorsal/ventral pattern formation	IEP IEP: Inferred from expression pattern	10767331	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	20589901	MGI
involved in locomotory behavior	IGI IGI: Inferred from genetic interaction	25915474	MGI
involved in memory	IGI IGI: Inferred from genetic interaction	25915474	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	21752929	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	12897786	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	15229182	MGI
involved in olfactory behavior	IGI IGI: Inferred from genetic interaction	25915474	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	17166916	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19951692	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17166916	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25915474	MGI
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25915474	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20589901	MGI
involved in regulation of intracellular transport	IMP IMP: Inferred from mutant phenotype	25915474	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21752929	MGI
involved in synapse organization	IGI IGI: Inferred from genetic interaction	25915474	MGI
acts upstream of or within trabecular meshwork development	IMP IMP: Inferred from mutant phenotype	20568247	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18076286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
LIM homeobox transcription factor 1-beta	GENA 191 LIM homeo box transcription factor 1B LIM/homeobox protein 1.2 LIM/homeobox protein LMX1B LMX-1.2

Lmx1b Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Lmx1b	O88609	Pspc1	Mus musculus	Q8R326	Anti Tag CoIP	23308148
Intra	Lmx1b	O88609	Pspc1	Mus musculus	Q8R326	Pull Down	23308148
Intra	Lmx1b	O88609	Pspc1	Mus musculus	Q8R326	Anti Bait CoIP	23308148
Intra	Lmx1b	O88609	Sfpq	Mus musculus	Q8VIJ6	Anti Tag CoIP	23308148

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07728	LMX1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21631	Lmx1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28149	Lmx1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lmx1b	NCBI	NCBI:4010