Fgf21 - fibroblast growth factor 21 Gene

Also Known as Fgf8c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170580

Summary

Predicted to enable Fibroblast Growth Factor receptor binding activity and growth factor activity. Involved in several processes, including cellular response to glucagon stimulus; endothelial cell apoptotic process; and negative regulation of cell death. Located in extracellular space. Orthologous to human FGF21 (Fibroblast Growth Factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Fgf21 Products (1)

mRNA Protein Name
NM_130752.2 NP_570108.1 fibroblast growth factor 21 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
23262585 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19660458 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
22166524 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
23118742 RGD
involved in endoplasmic reticulum unfolded protein response IEP
IEP: Inferred from expression pattern
23123503 RGD
involved in endothelial cell apoptotic process IEP
IEP: Inferred from expression pattern
22166524 RGD
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22166524 RGD
involved in positive regulation of triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
23262585 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22891896 RGD
involved in response to methionine IEP
IEP: Inferred from expression pattern
23052097 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25133427 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
22166524 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 21

  • fibroblast growth factor 8c

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11881 IUB288 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf21 NCBI NCBI:26291