FGF21 - fibroblast growth factor 21 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26291

About FGF21

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,755,524-48,758,330 (from NCBI)

This gene has 2 transcripts (splice variants), 103 orthologues and 21 paralogues. Restricted expression toward liver (RPKM 3.0).

Summary

Theis gene encodes a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]

FGF21 Products (1)

mRNA	Protein	Name
NM_019113.4	NP_061986.1	fibroblast growth factor 21 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18829467	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	17623664	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17623664	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF21 Protein Structure

FGF

0
100
209 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor 21

FGF21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FGF21	Q9NSA1	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	FGF21	Q9NSA1	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	FGF21	Q9NSA1	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	FGF21	Q9NSA1	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	FGF21	Q9NSA1	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	FGF21	Q9NSA1	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	FGF21	Q9NSA1	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	FGF21	Q9NSA1	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	FGF21	Q9NSA1	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	FGF21	Q9NSA1	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	FGF21	Q9NSA1	KLB	Homo sapiens	Q86Z14	SPR	19059246

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FGF21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7012	FGF-21 Protein, Human	Q9NSA1 (H29-S209, with an N-terminal Gly)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7345	FGF-21 Protein, Human (CHO, His)	Q9NSA1 (H29-S209)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70473	FGF-21 Protein, Human (His)	AAH18404.1 (H29-S209)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78442	FGF-21 Protein, Human (HEK293, mFc-Avi)	Q9NSA1 (H29-S209)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P70473AF	Animal-Free FGF-21 Protein, Human (His)	Q9NSA1 (H29-S209)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700719	FGF-21 Protein, Human (Biotinylated, HEK293, mFc-Avi)	Q9NSA1 (H29-S209)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701092	FGF-21 Protein, Human (181a.a)	Q9NSA1 (H29-S209)	≥ 95%, as determined by reducing SDS-PAGE.

FGF21 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83531	FGF21 Antibody (YA3276)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatocellular Clear Cell Carcinoma	Clear Cell Carcinoma Of The Liver Cells Hepatocellular Carcinoma, Clear Cell Type Clear Cell Hepatocellular Carcinoma
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Epilepsy, Idiopathic Generalized 4	EIG4 Epilepsy, Idiopathic Generalized, Susceptibility To 4 Idiopathic Generalized Epilepsy 4 Epilepsy, Idiopathic Generalized, Susceptibility To, 4 Epilepsy, Idiopathic Generalized Locus On Chromosome 10 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Cardiac Arrest	Cardiopulmonary Arrest Circulatory Arrest Heart Arrest
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Monckeberg Arteriosclerosis	Monckeberg Medial Calcific Sclerosis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Diabetes Mellitus	Diabetes
Alcoholic Cardiomyopathy	Cardiomyopathy, Alcoholic Alcohol-Induced Heart Muscle Disease Dilated Cardiomyopathy Secondary To Alcohol
Overnutrition
Acquired Metabolic Disease
Lysosomal Storage Disease	Lysosomal Storage Diseases Disorder Of Lysosomal Enzyme Inborn Lysosomal Enzyme Disorder Lysosomal Storage Metabolism Disorder Lysosomal Storage Disorder
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11881	IUB288	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FGF21	VGNC	VGNC:72647
Felis catus	FGF21	VGNC	VGNC:62252
Canis familiaris	FGF21	VGNC	VGNC:40848
Mus musculus	FGF21	MGD	MGI:1861377
Rattus norvegicus	FGF21	RGD	RGD:620175
Bos taurus	FGF21	VGNC	VGNC:28977
Others	FGF21	NCBI