Bco2 - beta-carotene oxygenase 2 Gene

Also Known as CMO2; Bcdo2; Bcmo2; B-diox-II

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170752

Summary

Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in isoprenoid metabolic process; regulation of mitochondrial membrane potential; and regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within retinal metabolic process and xanthophyll metabolic process. Located in mitochondrion. Is expressed in brain; embryo; liver; placenta; and yolk sac. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Bco2 Products (2)

mRNA Protein Name
NM_001359610.1 NP_001346539.1 carotenoid-cleaving dioxygenase, mitochondrial isoform 2
NM_133217.3 NP_573480.1 carotenoid-cleaving dioxygenase, mitochondrial isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta,beta-carotene-9',10'-cleaving oxygenase activity IDA
IDA: Inferred from direct assay
11278918 MGI
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IDA
IDA: Inferred from direct assay
11278918 MGI
Biological Process GO Annotation Evidence References Source
involved in carotene catabolic process IDA
IDA: Inferred from direct assay
11278918 MGI
involved in carotene metabolic process IDA
IDA: Inferred from direct assay
11278918 MGI
involved in carotenoid metabolic process IMP
IMP: Inferred from mutant phenotype
21106934 MGI
involved in regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
21106934 MGI
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21106934 MGI
acts upstream of or within retinal metabolic process IGI
IGI: Inferred from genetic interaction
25701869 MGI
involved in xanthophyll catabolic process IDA
IDA: Inferred from direct assay
21106934 MGI
acts upstream of or within xanthophyll metabolic process IMP
IMP: Inferred from mutant phenotype
25701869 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
21106934 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

carotenoid-cleaving dioxygenase, mitochondrial

beta,beta-carotene 9',10'-oxygenase

  • b,b-carotene-9',10'-dioxygenase

  • beta-carotene 9', 10'-dioxygenase 2

  • beta-carotene dioxygenase 2

  • beta-diox-II

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01447 BCO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21298 Bco2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27817 Bco2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bco2 NCBI NCBI:83875