Abcc4 - ATP binding cassette subfamily C member 4 Gene

Also Known as Mrp4; RGD1565953

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170924

Summary

Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Involved in several processes, including bile acid signaling pathway; positive regulation of smooth muscle cell proliferation; and response to xenobiotic stimulus. Located in basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]

Abcc4 Products (1)

mRNA Protein Name
NM_133411.1 NP_596902.1 ATP-binding cassette subfamily C member 4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18636120 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15047146 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
17544377 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15047146 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
located in external side of apical plasma membrane IDA
IDA: Inferred from direct assay
18619525 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette subfamily C member 4

multidrug resistance-associated protein 4

  • ABC-tranporter

  • ATP-binding cassette protein C4

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4

  • ATP-binding cassette, subfamily C (CFTR/MRP), member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19989A MK-571 sodium 99.75% Unkown
HY-129764 Prostaglandin F3α Substrate / Unkown
HY-RS00063 ABCC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20355 Abcc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26864 Abcc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc4 NCBI NCBI:10257