Cysltr2 - cysteinyl leukotriene receptor 2 Gene

Also Known as Cyslt2; RSBPT32

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170926

About Cysltr2

Primary_assembly 15: 48,189,073-48,304,136 reverse strand.mRatBN7.2:CM026988.1

This gene has 5 transcripts (splice variants), 55 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Thymus (RPKM 57.3), Lung (RPKM 32.) and 4 other tissues.

Summary

Predicted to enable G protein-coupled peptide receptor activity and cysteinyl Leukotriene Receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of angiogenesis; and positive regulation of cell death. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl Leukotriene Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr2 Products (1)

mRNA Protein Name
NM_133413.2 NP_596904.1 cysteinyl leukotriene receptor 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
17910051 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
17910051 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21055410 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
21105577 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cysltr2 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (23 - 299)

7tm_GPCRs

7tm_GPCRs: cd14964 (24 - 48)

7tm_GPCRs

7tm_GPCRs: cd14964 (57 - 78)

7tm_GPCRs

7tm_GPCRs: cd14964 (95 - 117)

7tm_GPCRs

7tm_GPCRs: cd14964 (140 - 156)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (229 - 251)

7tm_GPCRs

7tm_GPCRs: cd14964 (267 - 292)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

cysteinyl leukotriene receptor 2

  • cysteinyl leukotriene CysLT2 receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03497 CYSLTR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03498 Cysltr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03499 Cysltr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cysltr2 NCBI NCBI:57105