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Akap5 - A-kinase anchoring protein 5 Gene

Also Known as P150; Akap79; AKAP150

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171026

Summary

Enables several functions, including SH3 domain binding activity; enzyme binding activity; and signaling receptor binding activity. Involved in several processes, including nervous system development; regulation of Adenylate Cyclase activity; and regulation of metal ion transport. Located in several cellular components, including basolateral plasma membrane; cell projection membrane; and dendritic shaft. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human AKAP5 (A-kinase anchoring protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Akap5 Products (1)

mRNA	Protein	Name
NM_133515.2	NP_598199.2	A-kinase anchor protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	16940053	RGD
enables GABA receptor binding	IDA IDA: Inferred from direct assay	12595241	RGD
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	10939335	RGD
enables actin binding	IDA IDA: Inferred from direct assay	15930126	RGD
enables adenylate cyclase binding	IDA IDA: Inferred from direct assay	20410303	RGD
enables beta-2 adrenergic receptor binding	IPI IPI: Inferred from physical interaction	20395454	RGD
enables cadherin binding	IPI IPI: Inferred from physical interaction	15930126	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	10939335	RGD
enables kinase binding	IDA IDA: Inferred from direct assay	10939335	RGD
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	10939335	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12754513	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	12595241	RGD
enables protein kinase A regulatory subunit binding	IDA IDA: Inferred from direct assay	12826266	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	2538452	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18381233	RGD
enables protein phosphatase 2B binding	IDA IDA: Inferred from direct assay	10598575	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15141163	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10939335	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in hippocampus development	IEP IEP: Inferred from expression pattern	19535604	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	12135903	RGD
involved in negative regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	20410303	RGD
involved in negative regulation of monoatomic ion transport	IMP IMP: Inferred from mutant phenotype	18701070	RGD
involved in negative regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	16460836	RGD
involved in positive regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	20410303	RGD
involved in positive regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	22343722	RGD
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	18381233	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	19535604	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	17640527	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18381233	RGD
involved in protein-containing complex disassembly	IDA IDA: Inferred from direct assay	12177200	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	19169250	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	19169250	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	14732469	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	12150937	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	19535604	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	15951119	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12826266	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10939335	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	15930126	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	16510716	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	15951119	RGD
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	12177200	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	10939335	RGD
located in filopodium membrane	IDA IDA: Inferred from direct assay	12177200	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10939335	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10939335	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16510716	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15951119	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	22976297	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	10939335	RGD
is active in postsynaptic density, intracellular component	IMP IMP: Inferred from mutant phenotype	10939335	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
A-kinase anchor protein 5	A kinase (PRKA) anchor protein 5 A-kinase anchor protein 150 kDa AKAP 150 AKAP-5 RII-B-binding protein cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00520	AKAP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21476	Akap5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27994	Akap5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap5	NCBI	NCBI:9495