Folr1 - folate receptor alpha Gene

Also Known as Fbp1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171049

Summary

Enables folic acid binding activity. Predicted to be involved in several processes, including circulatory system development; regulation of signal transduction; and single fertilization. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Is anchored component of plasma membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Folr1 Products (1)

mRNA Protein Name
NM_133527.2 NP_598211.2 folate receptor alpha precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
8447363 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

folate receptor alpha

  • folate binding protein 1

  • folate receptor 1 (adult)

Recombinant Folr1 Proteins

Cat. No. Product Name Accession Purity
HY-P75775 FOLR1 Protein, Rat (HEK293, Fc) NP_598211.1 (A20-M231) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75776 FOLR1 Protein, Rat (HEK293, His) G3V8M6 (T25-M231) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132258A Mirvetuximab soravtansine (solution) 98.20% Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99225A Mirvetuximab (powder) 99.31% Phase 3

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05029 FOLR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05030 FOLR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16758 Folr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23197 Folr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99225 Mirvetuximab 99.88% Unkown
HY-P990941 Rinatabart 99.47% Unkown
HY-P992112 Eliroptamig Inhibitor / Unkown
HY-P990935 Opugotamig 99.67% Unkown
HY-P991695 Lazatatug Inhibitor / Unkown
HY-P992004 KHK2805 Inhibitor / Unkown
HY-P990417 Anti-FOLR1/FRA Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Folr1 NCBI NCBI:2348