Foxc1 - forkhead box C1 Gene

Also Known as ch; Mf1; Mf4; Fkh1; fkh-1; FREAC3; frkhda

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17300

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and vasculature development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; anterior segment dysgenesis 3; and glaucoma. Orthologous to human FOXC1 (forkhead box C1). [provided by Alliance of Genome Resources, Apr 2022]

Foxc1 Products (1)

mRNA Protein Name
NM_008592.2 NP_032618.2 forkhead box protein C1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
25808752 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18579532 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16678147 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25808752 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
25808752 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25808752 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
18579532 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of apoptotic process involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within artery morphogenesis IMP
IMP: Inferred from mutant phenotype
10479458 MGI
acts upstream of or within blood vessel development IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within blood vessel diameter maintenance IGI
IGI: Inferred from genetic interaction
16678147 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
4784576 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
10395790 MGI
acts upstream of or within cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
16839542 MGI
involved in cellular response to chemokine IMP
IMP: Inferred from mutant phenotype
18187037 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
19668217 MGI
involved in chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18187037 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
10767326 MGI
acts upstream of or within embryonic heart tube development IGI
IGI: Inferred from genetic interaction
16678147 MGI
involved in endochondral ossification IMP
IMP: Inferred from mutant phenotype
25808752 MGI
acts upstream of or within eye development IMP
IMP: Inferred from mutant phenotype
9635428 MGI
acts upstream of or within germ cell migration IMP
IMP: Inferred from mutant phenotype
16412416 MGI
involved in glomerular epithelium development IMP
IMP: Inferred from mutant phenotype
28223138 MGI
acts upstream of or within glycosaminoglycan metabolic process IMP
IMP: Inferred from mutant phenotype
4269479 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
10479458 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
4819561 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
5500588 MGI
acts upstream of or within lacrimal gland development IMP
IMP: Inferred from mutant phenotype
16470615 MGI
acts upstream of or within lymph vessel development IGI
IGI: Inferred from genetic interaction
16678147 MGI
involved in maintenance of lens transparency IMP
IMP: Inferred from mutant phenotype
22171010 MGI
involved in mesenchymal cell development IDA
IDA: Inferred from direct assay
24590069 MGI
acts upstream of or within mesenchymal cell differentiation IMP
IMP: Inferred from mutant phenotype
9635428 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
22171010 MGI
acts upstream of or within negative regulation of apoptotic process involved in outflow tract morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
involved in negative regulation of lymphangiogenesis IMP
IMP: Inferred from mutant phenotype
22171010 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
28223138 MGI
acts upstream of or within neural crest cell development IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
14512019 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
16412416 MGI
acts upstream of or within paraxial mesoderm formation IGI
IGI: Inferred from genetic interaction
11562355 MGI
involved in paraxial mesoderm formation IMP
IMP: Inferred from mutant phenotype
15196959 MGI
involved in positive regulation of core promoter binding IMP
IMP: Inferred from mutant phenotype
25808752 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
24590069 MGI
involved in positive regulation of hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24590069 MGI
involved in positive regulation of hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
24590069 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16678147 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18579532 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18187037 MGI
acts upstream of or within regulation of organ growth IGI
IGI: Inferred from genetic interaction
16839542 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
4784576 MGI
involved in somitogenesis IGI
IGI: Inferred from genetic interaction
11562355 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
10704385 MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
16678147 MGI
involved in vascular endothelial growth factor signaling pathway IMP
IMP: Inferred from mutant phenotype
22171010 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IGI
IGI: Inferred from genetic interaction
16839542 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25808752 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein C1

  • FREAC-3

  • MF-1

  • congenital hydrocephalus

  • forkhead-related protein FKHL7

  • forkhead-related transcription factor 3

  • mesoderm/mesenchyme forkhead 1

  • transcription factor FKH-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05041 FOXC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19196 Foxc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25684 Foxc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxc1 NCBI NCBI:2296