Mfge8 - milk fat globule EGF and factor V/VIII domain containing Gene

Also Known as P47; MP47; Mfgm; SED1; MFG-E8; lactadherin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17304

Summary

Enables Integrin binding activity; phosphatidylethanolamine binding activity; and phosphatidylserine binding activity. Involved in apoptotic cell clearance. Acts upstream of or within phagocytosis, engulfment; phagocytosis, recognition; and positive regulation of phagocytosis. Located in external side of plasma membrane and extracellular space. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; cap mesenchyme; central nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Mfge8 Products (2)

mRNA Protein Name
NM_001045489.1 NP_001038954.1 lactadherin isoform 2 precursor
NM_008594.2 NP_032620.2 lactadherin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
20826760 MGI
Biological Process GO Annotation Evidence References Source
involved in apoptotic cell clearance IDA
IDA: Inferred from direct assay
20826760 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12000961 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12000961 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lactadherin

  • EGF/factor VIII

  • milk fat globule glycoprotein

  • milk fat globule-EGF factor 8 protein

  • sperm surface protein SP47

Recombinant Mfge8 Proteins

Cat. No. Product Name Accession Purity
HY-P77749 MFG-E8 Protein, Mouse (HEK293, His) P21956 (A23-C463) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08381 MFGE8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19023 Mfge8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25512 Mfge8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mfge8 NCBI NCBI:4240