Mki67 - antigen identified by monoclonal antibody Ki 67 Gene

Also Known as Ki67; Ki-67; D630048A14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17345

Summary

Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic Cancer. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Apr 2022]

Mki67 Products (1)

mRNA Protein Name
NM_001081117.2 NP_001074586.2 proliferation marker protein Ki-67

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
12972605 MGI
NOT involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
26949251 MGI
acts upstream of or within cholangiocyte proliferation IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within hepatocyte proliferation IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: Inferred from direct assay
12355204 MGI
involved in regulation of chromatin organization IMP
IMP: Inferred from mutant phenotype
26949251 MGI
acts upstream of or within stem cell proliferation IDA
IDA: Inferred from direct assay
19303854 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
12355204 MGI
located in condensed chromosome IDA
IDA: Inferred from direct assay
12355204 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11731231 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
12355204 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15237214 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proliferation marker protein Ki-67

  • antigen KI-67 homolog

  • antigen Ki67 homolog

  • antigen identified by monoclonal antibody Ki-67 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175266 MI1013 99.10% Unkown
HY-RS08470 MKI67 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21649 Mki67 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28167 Mki67 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mki67 NCBI NCBI:4288