MKI67 - marker of proliferation Ki-67 Gene
Also Known as KIA; MIB-; MIB-1; PPP1R105
Species: Homo sapiens
About MKI67
This gene has 5 transcripts (splice variants), 127 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 18.5), lymph node (RPKM 8.4) and 12 other tissues.
Summary
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
MKI67 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145966.2 | NP_001139438.1 | proliferation marker protein Ki-67 isoform 2 |
| NM_002417.5 | NP_002408.3 | proliferation marker protein Ki-67 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10878014 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in regulation of chromosome segregation |
IDA
IDA: Inferred from direct assay
|
27362226 | GOA |
| involved in regulation of mitotic nuclear division |
IDA
IDA: Inferred from direct assay
|
27362226 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| colocalizes with condensed chromosome |
IDA
IDA: Inferred from direct assay
|
27362226 | GOA |
| located in nucleolus |
IDA
IDA: Inferred from direct assay
|
17577209 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
22378020 | GOA |
MKI67 Protein Structure
FHA: FHA domain (27 - 90)
PP1_bind: Protein phosphatase 1 binding (502 - 558)
K167R: K167R (NUC007) repeat (1002 - 1113)
K167R: K167R (NUC007) repeat (1124 - 1235)
K167R: K167R (NUC007) repeat (1246 - 1357)
K167R: K167R (NUC007) repeat (1368 - 1477)
K167R: K167R (NUC007) repeat (1489 - 1598)
K167R: K167R (NUC007) repeat (1610 - 1720)
K167R: K167R (NUC007) repeat (1732 - 1842)
K167R: K167R (NUC007) repeat (1854 - 1965)
K167R: K167R (NUC007) repeat (1976 - 2087)
K167R: K167R (NUC007) repeat (2098 - 2204)
K167R: K167R (NUC007) repeat (2216 - 2327)
K167R: K167R (NUC007) repeat (2337 - 2448)
K167R: K167R (NUC007) repeat (2459 - 2570)
K167R: K167R (NUC007) repeat (2582 - 2690)
K167R: K167R (NUC007) repeat (2702 - 2807)
K167R: K167R (NUC007) repeat (2820 - 2929)
- 0
- 600
- 1200
- 1800
- 2400
- 3000
- 3256 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
proliferation marker protein Ki-67 |
|
MKI67 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MKI67 | P46013 | NIFK | Homo sapiens | Q9BYG3 | 26949251 | |
|
Intra
|
MKI67 | P46013 | NIFK | Homo sapiens | Q9BYG3 | 16244663 | |
|
Intra
|
MKI67 | P46013 | NIFK | Homo sapiens | Q9BYG3 | 14659764 | |
|
Intra
|
MKI67 | P46013 | NIFK | Homo sapiens | Q9BYG3 | 16244663 | |
|
Intra
|
MKI67 | P46013 | KIF15 | Homo sapiens | Q9NS87 | 10878014 |
Recombinant MKI67 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72508 | Ki67/MKI67 Protein, Human (GST) | P46013-1 (M1-P120) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700257 | Ki67/MKI67 Protein, Human (His) | P46013-1 (V2962-E3254) | ≥ 95%, as determined by reducing SDS-PAGE. |
MKI67 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80505 | Ki67 Antibody (YA717) | IHC-P | Human, Mouse |
| HY-P80506 | Ki67 Antibody (YA322) | IHC-P, IHC-F, ICC/IF, FC, IF-Tissue, mIHC | Human, Mouse, Rat |
| HY-P80734 | Ki67 Antibody (YA001) | IHC-P, ICC/IF | Human, Mouse |
| HY-P84338 | Ki67 Antibody (YA4035) | WB, IHC-P, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P84338A | Ki67 Antibody (YA4035)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P86608 | Ki67 Antibody (YA6300) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cervical Intraepithelial Neoplasia |
|
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| Bowen'S Disease |
|
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| Oral Leukoplakia |
|
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| Leukoplakia |
|
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| Inverted Papilloma |
|
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| Transitional Cell Carcinoma |
|
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| Breast Ductal Carcinoma |
|
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| Larynx Cancer |
|
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| Keratoacanthoma |
|
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| Endometrial Hyperplasia |
|
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| Neuroendocrine Tumor |
|
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| Bladder Cancer |
|
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| Breast Fibroadenoma |
|
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| Barrett Esophagus |
|
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| Intracranial Meningioma |
|
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| Malignant Fibrous Histiocytoma |
|
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| Leiomyoma |
|
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| Laryngeal Squamous Cell Carcinoma |
|
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| Squamous Cell Carcinoma |
|
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| Breast Cancer |
|
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| Breast Disease |
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| Adenoma |
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| Basal Cell Carcinoma |
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| Parathyroid Carcinoma |
|
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| Benign Breast Phyllodes Tumor |
|
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| Papillary Carcinoma |
|
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| Smooth Muscle Tumor |
|
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| Actinic Keratosis |
|
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| Adenosarcoma |
|
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| Spinal Cord Melanoma |
|
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| Cervical Adenocarcinoma |
|
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| Bronchiectasis 1 |
|
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| Pulmonary Blastoma |
|
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| Adenoid Cystic Carcinoma |
|
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| B-Cell Lymphoma |
|
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| Benign Meningioma |
|
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| Fibrous Histiocytoma |
|
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| Endometrial Cancer |
|
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| Angiosarcoma |
|
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| Nephroma |
|
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| Colorectal Cancer |
|
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| Meningioma, Familial |
|
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| Prostate Cancer |
|
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| Cervical Squamous Cell Carcinoma |
|
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| Dermatofibrosarcoma Protuberans |
|
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| Sarcoma, Synovial |
|
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| Bladder Urothelial Carcinoma |
|
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| Anaplastic Astrocytoma |
|
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| Adrenal Cortical Carcinoma |
|
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| Melanoma In Congenital Melanocytic Nevus |
|
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| Gastrointestinal Stromal Tumor |
|
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| Langerhans Cell Histiocytosis |
|
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| Cellular Ependymoma |
|
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| Esophageal Cancer |
|
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| Lung Cancer |
|
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| Hepatocellular Carcinoma |
|
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| Gastric Cancer |
|
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| Colon Adenocarcinoma |
|
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| Renal Cell Carcinoma, Nonpapillary |
|
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| Melanoma |
|
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| Gastroesophageal Reflux |
|
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| Focal Segmental Glomerulosclerosis |
|
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| Microcephaly |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | MKI67 | VGNC | VGNC:106075 |
| Mus musculus | MKI67 | MGD | MGI:106035 |
| Canis familiaris | MKI67 | VGNC | VGNC:53000 |
| Bos taurus | MKI67 | VGNC | VGNC:55960 |
| Rattus norvegicus | MKI67 | RGD | RGD:1305476 |
| Others | MKI67 | NCBI |