Mlh1 - mutL homolog 1 Gene

Also Known as 1110035C23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17350

Summary

Enables chromatin binding activity and guanine/thymine mispair binding activity. Involved in positive regulation of isotype switching to IgA isotypes and positive regulation of isotype switching to IgG isotypes. Acts upstream of or within several processes, including gamete generation; meiotic nuclear division; and nucleic acid metabolic process. Located in condensed nuclear chromosome and male germ cell nucleus. Part of MutLalpha complex. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; oral epithelium; and respiratory system. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system Cancer (multiple); lung cancer; mismatch repair Cancer syndrome; and sporadic breast Cancer. Orthologous to human MLH1 (mutL homolog 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlh1 Products (2)

mRNA Protein Name
NM_001324522.1 NP_001311451.1 DNA mismatch repair protein Mlh1 isoform 2
NM_026810.2 NP_081086.2 DNA mismatch repair protein Mlh1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
14716311 MGI
enables guanine/thymine mispair binding IGI
IGI: Inferred from genetic interaction
16713580 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IGI
IGI: Inferred from genetic interaction
9560238 MGI
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
14562041 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
13679151 MGI
acts upstream of or within double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
15084308 MGI
acts upstream of or within female meiosis chromosome segregation IMP
IMP: Inferred from mutant phenotype
25533956 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
8674118 MGI
acts upstream of or within homologous chromosome segregation IMP
IMP: Inferred from mutant phenotype
25533956 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
14562041 MGI
acts upstream of or within isotype switching IMP
IMP: Inferred from mutant phenotype
12743174 MGI
acts upstream of or within leptotene IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within male meiosis chromosome segregation IMP
IMP: Inferred from mutant phenotype
25533956 MGI
acts upstream of or within male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
15467367 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: Inferred from direct assay
12091911 MGI
acts upstream of or within meiotic chromosome segregation IMP
IMP: Inferred from mutant phenotype
12217320 MGI
acts upstream of or within meiotic metaphase I homologous chromosome alignment IMP
IMP: Inferred from mutant phenotype
10385520 MGI
acts upstream of or within meiotic spindle midzone assembly IMP
IMP: Inferred from mutant phenotype
10385520 MGI
acts upstream of or within meiotic telomere clustering IMP
IMP: Inferred from mutant phenotype
17010969 MGI
acts upstream of or within mismatch repair IDA
IDA: Inferred from direct assay
10747038 MGI
acts upstream of or within mismatch repair IMP
IMP: Inferred from mutant phenotype
8674118 MGI
acts upstream of or within negative regulation of mitotic recombination IMP
IMP: Inferred from mutant phenotype
15480418 MGI
acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening IMP
IMP: Inferred from mutant phenotype
11337385 MGI
acts upstream of or within oogenesis IMP
IMP: Inferred from mutant phenotype
8674118 MGI
involved in positive regulation of isotype switching to IgA isotypes IMP
IMP: Inferred from mutant phenotype
10430621 MGI
involved in positive regulation of isotype switching to IgG isotypes IMP
IMP: Inferred from mutant phenotype
10430621 MGI
acts upstream of or within reciprocal meiotic recombination IMP
IMP: Inferred from mutant phenotype
8673133 MGI
acts upstream of or within resolution of meiotic recombination intermediates IMP
IMP: Inferred from mutant phenotype
10385520 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
10092760 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: Inferred from mutant phenotype
11828012 MGI
acts upstream of or within somatic recombination of immunoglobulin genes involved in immune response IGI
IGI: Inferred from genetic interaction
12743174 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
8674118 MGI
Cellular Component GO Annotation Evidence References Source
part of MutLalpha complex IDA
IDA: Inferred from direct assay
16713580 MGI
located in chiasma IDA
IDA: Inferred from direct assay
17291760 MGI
located in chromosome IDA
IDA: Inferred from direct assay
11934988 MGI
located in condensed chromosome IDA
IDA: Inferred from direct assay
12091911 MGI
located in condensed chromosome IMP
IMP: Inferred from mutant phenotype
8673133 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
18316482 MGI
located in late recombination nodule IDA
IDA: Inferred from direct assay
27760146 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
17696610 MGI
located in synaptonemal complex IDA
IDA: Inferred from direct assay
15467367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA mismatch repair protein Mlh1

  • colon cancer, nonpolyposis type 2

  • mutL protein homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147149 BPN-15477 Modulator 99.92% Unkown
HY-RS08489 MLH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19146 Mlh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25637 Mlh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlh1 NCBI NCBI:4292