Mre11a - MRE11A homolog A, double strand break repair nuclease Gene

Also Known as Mre11; Mre11b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17535

Summary

Predicted to enable identical protein binding activity; nuclease activity; and protein C-terminus binding activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Colocalizes with chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder Cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Apr 2022]

Mre11a Products (11)

mRNA Protein Name
NM_001310728.2 NP_001297657.1 double-strand break repair protein MRE11 isoform 2
NM_001411891.1 NP_001398820.1 double-strand break repair protein MRE11 isoform 1
NM_001411892.1 NP_001398821.1 double-strand break repair protein MRE11 isoform 2
NM_001411893.1 NP_001398822.1 double-strand break repair protein MRE11 isoform 3
NM_001411894.1 NP_001398823.1 double-strand break repair protein MRE11 isoform 3
NM_001411895.1 NP_001398824.1 double-strand break repair protein MRE11 isoform 4
NM_001411896.1 NP_001398825.1 double-strand break repair protein MRE11 isoform 5
NM_001411897.1 NP_001398826.1 double-strand break repair protein MRE11 isoform 6
NM_001411898.1 NP_001398827.1 double-strand break repair protein MRE11 isoform 6
NM_001411899.1 NP_001398828.1 double-strand break repair protein MRE11 isoform 7
NM_018736.4 NP_061206.1 double-strand break repair protein MRE11 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclease activity IMP
IMP: Inferred from mutant phenotype
18854157 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17429352 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA strand resection involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
18854157 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
9224597 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
14690604 MGI
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
18854157 MGI
acts upstream of or within double-strand break repair IMP
IMP: Inferred from mutant phenotype
17291760 MGI
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
18854157 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
17291760 MGI
acts upstream of or within mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
14690604 MGI
acts upstream of or within mitotic intra-S DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
14690604 MGI
Cellular Component GO Annotation Evidence References Source
part of Mre11 complex IDA
IDA: Inferred from direct assay
18854157 MGI
located in PML body IDA
IDA: Inferred from direct assay
23444137 MGI
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
23444137 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12687013 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double-strand break repair protein MRE11

  • MRE11 homolog 1

  • MRE11 homolog A

  • double-strand break repair protein MRE11A

  • meiotic recombination 11 homolog 1

  • meiotic recombination 11 homolog A

  • mmMRE11A

Mre11a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mre11 Q61216 Nbn Mus musculus Q9R207
Anti Bait CoIP
18854157
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08643 MRE11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24170 Mre11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown