Meis2 - Meis homeobox 2 Gene

Also Known as Mrg1; Stra10; A430109D20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17536

Summary

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Meis2 Products (15)

mRNA Protein Name
NM_001136072.2 NP_001129544.1 homeobox protein Meis2 isoform 1
NM_001159567.1 NP_001153039.1 homeobox protein Meis2 isoform 3
NM_001159568.1 NP_001153040.1 homeobox protein Meis2 isoform 4
NM_001159569.2 NP_001153041.1 homeobox protein Meis2 isoform 5
NM_001159570.2 NP_001153042.1 homeobox protein Meis2 isoform 6
NM_001346036.1 NP_001332965.1 homeobox protein Meis2 isoform 9
NM_001346038.1 NP_001332967.1 homeobox protein Meis2 isoform 10
NM_001346041.1 NP_001332970.1 homeobox protein Meis2 isoform 11
NM_001346044.1 NP_001332973.1 homeobox protein Meis2 isoform 12
NM_001346045.1 NP_001332974.1 homeobox protein Meis2 isoform 7
NM_001346047.1 NP_001332976.1 homeobox protein Meis2 isoform 8
NM_001346053.1 NP_001332982.1 homeobox protein Meis2 isoform 13
NM_001346055.1 NP_001332984.1 homeobox protein Meis2 isoform 13
NM_001346056.1 NP_001332985.1 homeobox protein Meis2 isoform 15
NM_010825.3 NP_034955.1 homeobox protein Meis2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12183364 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11279116 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18787068 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
17049510 MGI
enables transcription factor binding IDA
IDA: Inferred from direct assay
11279116 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within eye development IGI
IGI: Inferred from genetic interaction
12183364 MGI
involved in negative regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
11438208 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
25834037 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10842069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Meis2

  • Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2

  • meis1-related protein 1

  • myeloid ecotropic viral integration site-related gene 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134258 MEISi-1 Inhibitor 98.16% Unkown
HY-RS08326 MEIS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22635 Meis2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29150 Meis2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Meis2 NCBI NCBI:4212