Msx1 - msh homeobox 1 Gene

Also Known as msh; Hox7; Hox-7; Hox7.1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17701

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including embryonic nail plate morphogenesis; epithelial to mesenchymal transition; and odontogenesis of dentin-containing tooth. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study orofacial cleft and tooth agenesis. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; orofacial cleft 5; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Msx1 Products (1)

mRNA Protein Name
NM_010835.2 NP_034965.2 homeobox protein MSX-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22071108 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18285513 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8861098 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
8861098 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7916326 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
8861098 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
27741242 MGI
contributes to protein binding IPI
IPI: Inferred from physical interaction
10215616 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9697309 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8858134 MGI
contributes to transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
23371388 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16600910 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18667074 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
17601530 MGI
acts upstream of or within activation of meiosis IGI
IGI: Inferred from genetic interaction
22071108 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
21465616 MGI
acts upstream of or within bone morphogenesis IGI
IGI: Inferred from genetic interaction
17693062 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
12489152 MGI
acts upstream of or within cartilage morphogenesis IMP
IMP: Inferred from mutant phenotype
12489152 MGI
acts upstream of or within cell surface receptor signaling pathway involved in heart development IGI
IGI: Inferred from genetic interaction
18667074 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
21465616 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
21465616 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
21465616 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
15930102 MGI
acts upstream of or within embryonic nail plate morphogenesis IGI
IGI: Inferred from genetic interaction
21465616 MGI
involved in embryonic nail plate morphogenesis IMP
IMP: Inferred from mutant phenotype
11369996 MGI
involved in epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
11023873 MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation IGI
IGI: Inferred from genetic interaction
18667074 MGI
acts upstream of or within face morphogenesis IGI
IGI: Inferred from genetic interaction
20123092 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
16330189 MGI
involved in face morphogenesis IMP
IMP: Inferred from mutant phenotype
11369996 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15188430 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
17601530 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
17601530 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17601530 MGI
involved in inner ear development IMP
IMP: Inferred from mutant phenotype
7914451 MGI
acts upstream of or within mammary gland epithelium development IGI
IGI: Inferred from genetic interaction
10742104 MGI
acts upstream of mesenchymal cell apoptotic process IGI
IGI: Inferred from genetic interaction
19422820 MGI
involved in mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
11023873 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
15188430 MGI
acts upstream of or within middle ear morphogenesis IMP
IMP: Inferred from mutant phenotype
16330189 MGI
acts upstream of or within muscle organ development IPI
IPI: Inferred from physical interaction
15192231 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: Inferred from direct assay
17030628 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15192231 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
17601530 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17601530 MGI
acts upstream of negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24028588 MGI
involved in negative regulation of odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
24028588 MGI
acts upstream of or within negative regulation of striated muscle cell differentiation IDA
IDA: Inferred from direct assay
20004191 MGI
acts upstream of or within negative regulation of striated muscle cell differentiation IGI
IGI: Inferred from genetic interaction
20004191 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9369446 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8861098 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17030628 MGI
acts upstream of or within negative regulation of transcription regulatory region DNA binding IGI
IGI: Inferred from genetic interaction
9697309 MGI
involved in nose development IMP
IMP: Inferred from mutant phenotype
7914451 MGI
acts upstream of or within odontogenesis IGI
IGI: Inferred from genetic interaction
20123092 MGI
involved in odontogenesis IMP
IMP: Inferred from mutant phenotype
11023873 MGI
involved in odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
11369996 MGI
acts upstream of or within positive regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18667074 MGI
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
24028588 MGI
acts upstream of or within positive regulation of mesenchymal cell apoptotic process IGI
IGI: Inferred from genetic interaction
19422820 MGI
involved in positive regulation of odontogenesis IMP
IMP: Inferred from mutant phenotype
7914451 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
8898217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8898217 MGI
acts upstream of or within regulation of odontogenesis IGI
IGI: Inferred from genetic interaction
20123092 MGI
involved in regulation of odontogenesis IMP
IMP: Inferred from mutant phenotype
29148101 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
16330189 MGI
involved in roof of mouth development IMP
IMP: Inferred from mutant phenotype
7914451 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IGI
IGI: Inferred from genetic interaction
21465616 MGI
acts upstream of or within stem cell differentiation IGI
IGI: Inferred from genetic interaction
17693062 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
8898217 MGI
Cellular Component GO Annotation Evidence References Source
is active in nuclear periphery IDA
IDA: Inferred from direct assay
16600910 MGI
located in nucleus IGI
IGI: Inferred from genetic interaction
20004191 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
18285513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein MSX-1

  • homeo box, msh-like 1

  • homeobox protein Hox-7

  • homeobox, msh-like 1

  • hox-7.1

  • msh homeobox 1-like protein

  • muscle-segment homeobox

Msx1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Msx1 P13297 Ndn Mus musculus P25233
Anti Bait CoIP
15272023
Intra
Msx1 P13297 H1-5 Mus musculus P43276
Pull Down
15192231
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08733 MSX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19920 Msx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26422 Msx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Msx1 NCBI NCBI:4487