Msx1 - msh homeobox 1 Gene

Mus musculus

Also known as msh; Hox7; Hox-7; Hox7.1

Gene ID: 17701 | Gene type: protein coding

About Msx1

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including embryonic nail plate morphogenesis; epithelial to mesenchymal transition; and odontogenesis of dentin-containing tooth. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study orofacial cleft and tooth agenesis. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; orofacial cleft 5; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Msx1 Products(1)

mRNA	Protein	Name
NM_010835.2	NP_034965.2	homeobox protein MSX-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22071108	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18285513	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8861098	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8861098	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7916326	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8861098	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27741242	MGI
contributes to protein binding	IPI IPI: Inferred from physical interaction	10215616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9697309	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8858134	MGI
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	23371388	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16600910	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	18590716	MGI
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within activation of meiosis	IGI IGI: Inferred from genetic interaction	22071108	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within bone morphogenesis	IGI IGI: Inferred from genetic interaction	17693062	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	12489152	MGI
acts upstream of or within cartilage morphogenesis	IMP IMP: Inferred from mutant phenotype	12489152	MGI
acts upstream of or within cell surface receptor signaling pathway involved in heart development	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	15930102	MGI
acts upstream of or within embryonic nail plate morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
involved in embryonic nail plate morphogenesis	IMP IMP: Inferred from mutant phenotype	11369996	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	11023873	MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within face morphogenesis	IGI IGI: Inferred from genetic interaction	20123092	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	16330189	MGI
involved in face morphogenesis	IMP IMP: Inferred from mutant phenotype	11369996	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	15188430	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17601530	MGI
involved in inner ear development	IMP IMP: Inferred from mutant phenotype	7914451	MGI
acts upstream of or within mammary gland epithelium development	IGI IGI: Inferred from genetic interaction	10742104	MGI
acts upstream of mesenchymal cell apoptotic process	IGI IGI: Inferred from genetic interaction	19422820	MGI
involved in mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	11023873	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	15188430	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	16330189	MGI
acts upstream of or within muscle organ development	IPI IPI: Inferred from physical interaction	15192231	MGI
acts upstream of or within negative regulation of DNA binding	IDA IDA: Inferred from direct assay	17030628	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15192231	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24028588	MGI
involved in negative regulation of odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	24028588	MGI
acts upstream of or within negative regulation of striated muscle cell differentiation	IDA IDA: Inferred from direct assay	20004191	MGI
acts upstream of or within negative regulation of striated muscle cell differentiation	IGI IGI: Inferred from genetic interaction	20004191	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9369446	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8861098	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17030628	MGI
acts upstream of or within negative regulation of transcription regulatory region DNA binding	IGI IGI: Inferred from genetic interaction	9697309	MGI
involved in nose development	IMP IMP: Inferred from mutant phenotype	7914451	MGI
acts upstream of or within odontogenesis	IGI IGI: Inferred from genetic interaction	20123092	MGI
involved in odontogenesis	IMP IMP: Inferred from mutant phenotype	11023873	MGI
involved in odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	11369996	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18667074	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	24028588	MGI
acts upstream of or within positive regulation of mesenchymal cell apoptotic process	IGI IGI: Inferred from genetic interaction	19422820	MGI
involved in positive regulation of odontogenesis	IMP IMP: Inferred from mutant phenotype	7914451	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8898217	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8898217	MGI
acts upstream of or within regulation of odontogenesis	IGI IGI: Inferred from genetic interaction	20123092	MGI
involved in regulation of odontogenesis	IMP IMP: Inferred from mutant phenotype	29148101	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	16330189	MGI
involved in roof of mouth development	IMP IMP: Inferred from mutant phenotype	7914451	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within stem cell differentiation	IGI IGI: Inferred from genetic interaction	17693062	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	8898217	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nuclear periphery	IDA IDA: Inferred from direct assay	16600910	MGI
located in nucleus	IGI IGI: Inferred from genetic interaction	20004191	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	18285513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein MSX-1

homeo box, msh-like 1	homeobox protein Hox-7
homeobox, msh-like 1	hox-7.1
msh homeobox 1-like protein	muscle-segment homeobox

Msx1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Msx1	P13297	Ndn	Mus musculus	P25233	Anti Bait CoIP	15272023
Intra	Msx1	P13297	H1-5	Mus musculus	P43276	Pull Down	15192231

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08733	MSX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19920	Msx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26422	Msx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Msx1	NCBI	NCBI:4487

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