Mxi1 - MAX interactor 1, dimerization protein Gene

Also Known as Mad2; Gm10197; bHLHc11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17859

Summary

This gene encodes a protein containing a helix-loop-helix domain characteristic of transcription factors, which allows heterodimerization and sequence-specific DNA binding. The encoded protein is related to a family of Myc/Max/Mad proteins that are involved in the regulation of several cellular processes. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate Myc function. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Mxi1 Products (7)

mRNA Protein Name
NM_001008542.3 NP_001008542.2 max-interacting protein 1 isoform b
NM_001008543.3 NP_001008543.1 max-interacting protein 1 isoform c
NM_001360345.1 NP_001347274.1 max-interacting protein 1 isoform c
NM_001360346.1 NP_001347275.1 max-interacting protein 1 isoform c
NM_001360347.1 NP_001347276.1 max-interacting protein 1 isoform c
NM_001360348.1 NP_001347277.1 max-interacting protein 1 isoform d
NM_010847.4 NP_034977.1 max-interacting protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8649810 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst formation IMP
IMP: Inferred from mutant phenotype
27869233 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15467743 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15467743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

max-interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08864 MXI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21382 Mxi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27901 Mxi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mxi1 NCBI NCBI:4601