Myh9 - myosin, heavy polypeptide 9, non-muscle Gene

Also Known as Fltn; Myhn1; Myhn-1; TU72.6; NMHCIIA; NMMHC-A; NMMHC-IIA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17886

Summary

Enables protein domain specific binding activity. Involved in several processes, including cortical granule exocytosis; negative regulation of actin filament severing; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within several processes, including establishment of T cell polarity; microtubule Cytoskeleton organization; and myoblast fusion. Located in several cellular components, including cortical granule; cytoskeleton; and immunological synapse. Part of Myosin II complex. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; early embryo; future spinal cord; heart and pericardium; and sensory organ. Used to study MYH-9 related disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (Myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]

Myh9 Products (1)

mRNA Protein Name
NM_022410.3 NP_071855.2 myosin-9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
28114272 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16407977 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
23325791 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in actin filament capping IDA
IDA: Inferred from direct assay
23325791 MGI
NOT involved in actin filament polymerization IDA
IDA: Inferred from direct assay
23325791 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
16407977 MGI
involved in cell morphogenesis IMP
IMP: Inferred from mutant phenotype
15292239 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
15064761 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15292239 MGI
involved in cortical granule exocytosis IMP
IMP: Inferred from mutant phenotype
31118423 MGI
involved in endodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
15292239 MGI
acts upstream of or within establishment of T cell polarity IMP
IMP: Inferred from mutant phenotype
15064761 MGI
acts upstream of or within establishment of meiotic spindle localization IDA
IDA: Inferred from direct assay
9725909 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15555549 MGI
acts upstream of or within meiotic spindle organization IDA
IDA: Inferred from direct assay
9725909 MGI
acts upstream of or within myoblast fusion IMP
IMP: Inferred from mutant phenotype
16895968 MGI
involved in negative regulation of actin filament severing IMP
IMP: Inferred from mutant phenotype
23325791 MGI
involved in phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
23325791 MGI
involved in positive regulation of protein processing in phagocytic vesicle IMP
IMP: Inferred from mutant phenotype
23325791 MGI
acts upstream of or within regulation of cell shape IMP
IMP: Inferred from mutant phenotype
16895968 MGI
acts upstream of or within uropod organization IMP
IMP: Inferred from mutant phenotype
15064761 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
15292239 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
9725909 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
12893741 MGI
located in cortical granule IDA
IDA: Inferred from direct assay
31118423 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9725909 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
16895968 MGI
colocalizes with focal adhesion IDA
IDA: Inferred from direct assay
23325791 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
15064761 MGI
part of myosin II complex IDA
IDA: Inferred from direct assay
21126233 MGI
part of myosin complex IDA
IDA: Inferred from direct assay
8482409 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
16012337 MGI
located in spindle IDA
IDA: Inferred from direct assay
9725909 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
16895968 MGI
located in uropod IDA
IDA: Inferred from direct assay
15064761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-9

  • NMHC II-A

  • NMMHC II-a

  • cellular myosin heavy chain, type A

  • flectin

  • myosin IIA

  • myosin heavy chain IX

  • non-muscle myosin heavy chain IIa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08908 MYH9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18249 Myh9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24729 Myh9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh9 NCBI NCBI:4627