Ncoa1 - nuclear receptor coactivator 1 Gene

Also Known as SRC1; NRC-1; SRC-1; SRC-a; KAT13A; NCoA-1; mNRC-1; bHLHe74

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17977

Summary

Enables DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including histone H4 acetylation; positive regulation of transcription from RNA polymerase II promoter by galactose; and regulation of cellular response to drug. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; labyrinthine layer morphogenesis; and regulation of thyroid hormone mediated signaling pathway. Predicted to be located in several cellular components, including chromatin; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Used to study obesity and thyroid hormone resistance syndrome. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa1 Products (11)

mRNA Protein Name
NM_001408597.1 NP_001395526.1 nuclear receptor coactivator 1 isoform 1
NM_001408598.1 NP_001395527.1 nuclear receptor coactivator 1 isoform 1
NM_001408599.1 NP_001395528.1 nuclear receptor coactivator 1 isoform 1
NM_001408600.1 NP_001395529.1 nuclear receptor coactivator 1 isoform 1
NM_001408601.1 NP_001395530.1 nuclear receptor coactivator 1 isoform 1
NM_001408602.1 NP_001395531.1 nuclear receptor coactivator 1 isoform 2
NM_001408603.1 NP_001395532.1 nuclear receptor coactivator 1 isoform 3
NM_001408604.1 NP_001395533.1 nuclear receptor coactivator 1 isoform 4
NM_001408605.1 NP_001395534.1 nuclear receptor coactivator 1 isoform 5
NM_001408606.1 NP_001395535.1 nuclear receptor coactivator 1 isoform 6
NM_010881.3 NP_035011.1 nuclear receptor coactivator 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15681609 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
12446761 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10934189 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16148126 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
16723356 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to Thyroglobulin triiodothyronine IGI
IGI: Inferred from genetic interaction
24550004 MGI
acts upstream of or within labyrinthine layer morphogenesis IGI
IGI: Inferred from genetic interaction
20685850 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16723356 MGI
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
16723356 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10934189 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15155786 MGI
acts upstream of or within regulation of thyroid hormone receptor signaling pathway IGI
IGI: Inferred from genetic interaction
24550004 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex EXP
EXP: Inferred from Experiment
17215127 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor coactivator 1

  • nuclear receptor coactivator protein 1

  • steroid receptor coactivator 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173033 MI-883 99.57% Unkown
HY-RS09089 NCOA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146288 LXR agonist 2 Agonist / Unkown
HY-RS22672 Ncoa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29186 Ncoa1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncoa1 NCBI NCBI:8648