Nedd9 - neural precursor cell expressed, developmentally down-regulated gene 9 Gene

Also Known as CasL; HEF1; MEF1; p105; Cas-L; Nedd-9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18003

Summary

Predicted to enable protein tyrosine kinase binding activity. Acts upstream of or within activation of GTPase activity. Located in nucleus and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb mesenchyme; and nose. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9). [provided by Alliance of Genome Resources, Apr 2022]

Nedd9 Products (2)

mRNA Protein Name
NM_001111324.2 NP_001104794.1 enhancer of filamentation 1 isoform 1
NM_017464.5 NP_059492.3 enhancer of filamentation 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20956287 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of GTPase activity IGI
IGI: Inferred from genetic interaction
25621495 MGI
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
26683084 MGI
involved in lymphocyte migration into lymphoid organs IMP
IMP: Inferred from mutant phenotype
16148091 MGI
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
25059660 MGI
involved in positive regulation of dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
26683084 MGI
involved in positive regulation of immunological synapse formation IMP
IMP: Inferred from mutant phenotype
27359298 MGI
involved in positive regulation of lymphocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
16148091 MGI
involved in positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
27336669 MGI
involved in positive regulation of protein localization IMP
IMP: Inferred from mutant phenotype
27359298 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
27359298 MGI
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
27359298 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19376971 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
19376971 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

enhancer of filamentation 1

  • CRK-associated substrate-related protein

  • Crk-associated substrate lymphocyte-specific protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183628 MEAP Modulator / Unkown
HY-RS09182 NEDD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21663 Nedd9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28181 Nedd9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nedd9 NCBI NCBI:4739