Nek1 - NIMA (never in mitosis gene a)-related expressed kinase 1 Gene
Also Known as kat; D8Ertd790e
Species: Mus musculus
Summary
Enables 14-3-3 protein binding activity. Involved in regulation of DNA damage checkpoint. Acts upstream of or within several processes, including cellular response to DNA damage stimulus; response to ionizing radiation; and spermatogenesis. Located in centrosome and nucleus. Is expressed in several structures, including central nervous system; ganglia; gonad; lung; and spleen. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Nek1 Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001293637.1 | NP_001280566.1 | serine/threonine-protein kinase Nek1 isoform 1 |
| NM_001293638.1 | NP_001280567.1 | serine/threonine-protein kinase Nek1 isoform 2 |
| NM_001293639.1 | NP_001280568.1 | serine/threonine-protein kinase Nek1 isoform 4 |
| NM_001414226.1 | NP_001401155.1 | serine/threonine-protein kinase Nek1 isoform 5 |
| NM_001414227.1 | NP_001401156.1 | serine/threonine-protein kinase Nek1 isoform 6 |
| NM_001414228.1 | NP_001401157.1 | serine/threonine-protein kinase Nek1 isoform 7 |
| NM_001414229.1 | NP_001401158.1 | serine/threonine-protein kinase Nek1 isoform 8 |
| NM_001414230.1 | NP_001401159.1 | serine/threonine-protein kinase Nek1 isoform 9 |
| NM_175089.4 | NP_780298.2 | serine/threonine-protein kinase Nek1 isoform 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables 14-3-3 protein binding |
IDA
IDA: Inferred from direct assay
|
28235073 | MGI |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within DNA damage response |
IMP
IMP: Inferred from mutant phenotype
|
15604234 | MGI |
| acts upstream of or within kidney development |
IMP
IMP: Inferred from mutant phenotype
|
10618398 | MGI |
| acts upstream of or within multicellular organism growth |
IMP
IMP: Inferred from mutant phenotype
|
10618398 | MGI |
| involved in regulation of DNA damage checkpoint |
IMP
IMP: Inferred from mutant phenotype
|
18843199 | MGI |
| acts upstream of or within response to ionizing radiation |
IMP
IMP: Inferred from mutant phenotype
|
15604234 | MGI |
| acts upstream of or within spermatogenesis |
IMP
IMP: Inferred from mutant phenotype
|
10618398 | MGI |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in centrosome |
IDA
IDA: Inferred from direct assay
|
16267153 | MGI |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
19699716 | MGI |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein kinase Nek1 |
|
|
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service