2. Gene
  3. Nos3 - nitric oxide synthase 3, endothelial cell Gene

Nos3 - nitric oxide synthase 3, endothelial cell Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as eNOS; Nos-3; ecNOS; 2310065A03Rik

Gene ID: 18127 | Gene type: protein coding

About Nos3

Chromosome 5: 24,569,808-24,589,472 forward strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 114 orthologues, 5 paralogues and is associated with 243 phenotypes. Broad expression in subcutaneous fat pad adult (RPKM 22.), mammary gland adult (RPKM 2.1) and 26 other tissues.

Summary

Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; and persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ Cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]

Nos3 Products(1)

mRNA Protein Name
NM_008713.4 NP_032739.3 nitric oxide synthase, endothelial

Nos3 Protein Structure

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (66 - 478)

Flavodoxin_1

Flavodoxin_1: pfam00258 (520 - 696)

FNR_like

FNR_like: cl06868 (760 - 1162)

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  • 1202 a.a.
Protein Preferred Names Protein Names

nitric oxide synthase, endothelial

EC-NOS

NOS type III

NOSIII

cNOS

constitutive NOS

endothelial NOS

endothelial nitric oxide synthase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18732A L-NMMA acetate Inhibitor 98.58% Phase 4
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09440 NOS3 Human Pre-designed siRNA Set A / Unkown
HY-RS09441 Nos3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09442 Nos3 Rat Pre-designed siRNA Set A / Unkown
HY-N8761 Kihadanin A Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nos3 NCBI NCBI:4846