Uhrf1 - ubiquitin-like, containing PHD and RING finger domains, 1 Gene

Also Known as Np95; ICBP90; RNF106

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18140

Summary

Enables several functions, including hemi-methylated DNA-binding activity; histone binding activity; and ubiquitin protein Ligase activity. Involved in maintenance of DNA methylation; negative regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in heterochromatin; nuclear matrix; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Uhrf1 Products (8)

mRNA Protein Name
NM_001111078.2 NP_001104548.1 E3 ubiquitin-protein ligase UHRF1 isoform A
NM_001111079.2 NP_001104549.1 E3 ubiquitin-protein ligase UHRF1 isoform B
NM_001111080.2 NP_001104550.1 E3 ubiquitin-protein ligase UHRF1 isoform B
NM_001413357.1 NP_001400286.1 E3 ubiquitin-protein ligase UHRF1 isoform C
NM_001413358.1 NP_001400287.1 E3 ubiquitin-protein ligase UHRF1 isoform D
NM_001413359.1 NP_001400288.1 E3 ubiquitin-protein ligase UHRF1 isoform E
NM_001413360.1 NP_001400289.1 E3 ubiquitin-protein ligase UHRF1 isoform D
NM_010931.4 NP_035061.3 E3 ubiquitin-protein ligase UHRF1 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hemi-methylated DNA-binding IDA
IDA: Inferred from direct assay
17994007 MGI
enables histone H3 ubiquitin ligase activity IDA
IDA: Inferred from direct assay
14993289 MGI
enables histone binding IDA
IDA: Inferred from direct assay
14993289 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
14993289 MGI
enables methylated histone binding IDA
IDA: Inferred from direct assay
21489993 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17994007 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
14993289 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: Inferred from mutant phenotype
17673620 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21489993 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
14993289 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
17994007 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
14993289 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17994007 MGI
located in replication fork IDA
IDA: Inferred from direct assay
17994007 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase UHRF1

  • RING-type E3 ubiquitin transferase UHRF1

  • mUhrf1

  • nuclear protein 95

  • nuclear zinc finger protein Np95

  • ubiquitin-like PHD and RING finger domain-containing protein 1

  • ubiquitin-like-containing PHD and RING finger domains protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125292 NV03 99.77% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uhrf1 NCBI NCBI:29128