Npr1 - natriuretic peptide receptor 1 Gene

Also Known as GC-A; NPRA; Pndr; NPR-A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18160

Summary

Enables Guanylate Cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; limb; and respiratory system. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Npr1 Products (1)

mRNA Protein Name
NM_008727.5 NP_032753.5 atrial natriuretic peptide receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanylate cyclase activity IDA
IDA: Inferred from direct assay
11997476 MGI
enables guanylate cyclase activity IMP
IMP: Inferred from mutant phenotype
11997476 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of blood pressure IDA
IDA: Inferred from direct assay
12727932 MGI
NOT acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11997476 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atrial natriuretic peptide receptor 1

  • ANP-A

  • ANPR-A

  • Nppa receptor

  • atrial natriuretic peptide receptor type A

  • guanylate cyclase A

  • guanylyl cyclase-A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990921 Imelciment / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1419 AP 811 Antagonist 99.64% Unkown
HY-153650 JS11 Inhibitor 99.22% Unkown
HY-177062 NPRA agonist-11 Agonist / Unkown
HY-P1419A AP 811 acetate Antagonist / Unkown
HY-RS09497 NPR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18627 Npr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25113 Npr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990951 Vixticibart Agonist 97.83% Unkown
HY-P991121 Baloncibart Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npr1 NCBI NCBI:4881