Npy5r - neuropeptide Y receptor Y5 Gene

Also Known as Y5R; NPY5-R; NPYY5-R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18168

About Npy5r

Chromosome 8: 67,132,617-67,140,780 reverse strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 137 orthologues, 55 paralogues and is associated with 16 phenotypes. Biased expression in cortex adult (RPKM 1.1), frontal lobe adult (RPKM 1.) and 5 other tissues.

Summary

Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within chemical synaptic transmission. Located in membrane and neuron projection. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (Neuropeptide Y Receptor Y5). [provided by Alliance of Genome Resources, Apr 2022]

Npy5r Products (3)

mRNA Protein Name
NM_001358957.1 NP_001345886.1 neuropeptide Y receptor type 5
NM_001358958.1 NP_001345887.1 neuropeptide Y receptor type 5
NM_016708.3 NP_057917.2 neuropeptide Y receptor type 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables neuropeptide Y receptor activity IDA
IDA: Inferred from direct assay
9802393 MGI
enables pancreatic polypeptide receptor activity IDA
IDA: Inferred from direct assay
9802393 MGI
enables peptide YY receptor activity IDA
IDA: Inferred from direct assay
9802393 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10557353 MGI
involved in synaptic signaling via neuropeptide EXP
EXP: Inferred from Experiment
22190627 MGI
involved in synaptic signaling via neuropeptide IDA
IDA: Inferred from direct assay
22190627 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
22190627 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22190627 MGI
located in membrane IDA
IDA: Inferred from direct assay
9802393 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
24316073 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
22190627 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Npy5r Protein Structure

7tmA_NPY5R

7tmA_NPY5R: cd15398 (62 - 455)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (63 - 89)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (96 - 121)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (134 - 164)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (175 - 196)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (228 - 257)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (380 - 410)

7tmA_NPY5R

7tmA_NPY5R: cd15398 (423 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 466 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 5

  • NPY-Y5 receptor

  • Y5 receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107734 L 152804 Antagonist 99.89% Unkown
HY-RS09520 NPY5R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09521 Npy5r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09522 Npy5r Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npy5r NCBI NCBI:4889