NPY5R - neuropeptide Y receptor Y5 Gene

Also Known as NPYR5; NPY5-R; NPYY5-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4889

About NPY5R

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,343,892-163,352,403 (from NCBI)

This gene has 3 transcripts (splice variants), 137 orthologues and 33 paralogues. Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues.

Summary

The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]

NPY5R Products (3)

mRNA Protein Name
NM_001317091.2 NP_001304020.1 neuropeptide Y receptor type 5
NM_001317092.2 NP_001304021.1 neuropeptide Y receptor type 5
NM_006174.4 NP_006165.1 neuropeptide Y receptor type 5

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cardiac left ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19593212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPY5R Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

neuropeptide Y receptor type 5

  • NPY-Y5 receptor

Related Diseases

Diseases Alias
Dihydropyrimidinase Deficiency

  • Dihydropyrimidinuria

  • Dpys Deficiency

  • Dph Deficiency

  • DPYSD

  • Dihydrouracil Amidohydrolase Deficiency

  • Dihydropyrimidinuria Due To Dpys Deficiency
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107734 L 152804 Antagonist 99.89% Unkown
HY-RS09520 NPY5R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09521 Npy5r Mouse Pre-designed siRNA Set A / Unkown
HY-RS09522 Npy5r Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NPY5R VGNC VGNC:54273
Mus musculus NPY5R MGD MGI:108082
Bos taurus NPY5R VGNC VGNC:32224
Rattus norvegicus NPY5R RGD RGD:3199
Felis catus NPY5R VGNC VGNC:68539
Macaca mulatta NPY5R VGNC VGNC:75395
Others NPY5R NCBI