Slc11a2 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Gene

Also Known as mk; van; DCT1; DMT1; Nramp2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18174

Summary

Enables cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; and proton transmembrane transporter activity. Acts upstream of or within several processes, including cation transport; erythrocyte development; and multicellular organismal iron ion homeostasis. Located in several cellular components, including brush border membrane; endosome; and extracellular vesicle. Is integral component of plasma membrane. Is expressed in embryo; intestine; small intestine; and yolk sac. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a2 Products (3)

mRNA	Protein	Name
NM_001146161.1	NP_001139633.1	natural resistance-associated macrophage protein 2 isoform 1
NM_001356952.1	NP_001343881.1	natural resistance-associated macrophage protein 2 isoform 3
NM_008732.2	NP_032758.2	natural resistance-associated macrophage protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cobalt ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	12522007	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cobalt ion transport	IDA IDA: Inferred from direct assay	12724326	MGI
acts upstream of or within dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	19211831	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	15849611	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	807277	MGI
acts upstream of or within heme biosynthetic process	IMP IMP: Inferred from mutant phenotype	11739192	MGI
acts upstream of or within iron import into cell	IMP IMP: Inferred from mutant phenotype	11739192	MGI
acts upstream of or within iron ion transport	IMP IMP: Inferred from mutant phenotype	807277	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	19211831	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	5070129	MGI
acts upstream of or within porphyrin-containing compound biosynthetic process	IMP IMP: Inferred from mutant phenotype	658175	MGI
acts upstream of or within porphyrin-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	4404581	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in brush border membrane	IGI IGI: Inferred from genetic interaction	19252488	MGI
located in endosome	IDA IDA: Inferred from direct assay	16227996	MGI
located in extracellular vesicle	IDA IDA: Inferred from direct assay	27462458	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16227996	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
natural resistance-associated macrophage protein 2	DMT-1 NRAMP 2 divalent cation transporter 1 divalent metal transporter 1 microcytic anemia, viable anaemia solute carrier family 11 member 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180199	GPX4-IN-21		/	Unkown
HY-RS12995	SLC11A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20644	Slc11a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27154	Slc11a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc11a2	NCBI	NCBI:4891