Nrp2 - neuropilin 2 Gene

Also Known as Np2; Np-2; Npn2; Npn-2; 1110048P06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18187

Summary

Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Located in axon. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and limb. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nrp2 Products (6)

mRNA Protein Name
NM_001077403.1 NP_001070871.1 neuropilin-2 isoform 1 precursor
NM_001077404.1 NP_001070872.1 neuropilin-2 isoform 2 precursor
NM_001077405.1 NP_001070873.1 neuropilin-2 isoform 4 precursor
NM_001077406.1 NP_001070874.1 neuropilin-2 isoform 5 precursor
NM_001077407.1 NP_001070875.1 neuropilin-2 isoform 6 precursor
NM_010939.2 NP_035069.2 neuropilin-2 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10520994 MGI
enables semaphorin receptor activity IDA
IDA: Inferred from direct assay
15239958 MGI
Biological Process GO Annotation Evidence References Source
involved in axon extension involved in axon guidance IMP
IMP: Inferred from mutant phenotype
22790009 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15814794 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in dorsal root ganglion morphogenesis IMP
IMP: Inferred from mutant phenotype
19386662 MGI
involved in facial nerve structural organization IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in facioacoustic ganglion development IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
IMP: Inferred from mutant phenotype
21059704 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
12852851 MGI
acts upstream of or within negative chemotaxis IGI
IGI: Inferred from genetic interaction
16319111 MGI
acts upstream of or within negative chemotaxis IMP
IMP: Inferred from mutant phenotype
15814794 MGI
involved in nerve development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in neural crest cell migration involved in autonomic nervous system development IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
21059704 MGI
involved in outflow tract septum morphogenesis IGI
IGI: Inferred from genetic interaction
26053665 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
20010807 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
20010807 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sensory neuron axon guidance IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in sympathetic ganglion development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sympathetic neuron projection extension IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sympathetic neuron projection guidance IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in trigeminal ganglion development IMP
IMP: Inferred from mutant phenotype
18356247 MGI
acts upstream of or within trunk neural crest cell migration IMP
IMP: Inferred from mutant phenotype
16319111 MGI
involved in ventral trunk neural crest cell migration IMP
IMP: Inferred from mutant phenotype
19386662 MGI
involved in vestibulocochlear nerve structural organization IMP
IMP: Inferred from mutant phenotype
18356247 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15677725 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20010807 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20010807 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
25143608 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuropilin-2

  • vascular endothelial cell growth factor 165 receptor 2

Recombinant Nrp2 Proteins

Cat. No. Product Name Accession Purity
HY-P73315 Neuropilin-2 Protein, Mouse (HEK293, His) O35375 (M1-P864) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990782 Efzofitimod 99.29% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11647A RPARPAR acetate Ligand 99.47% Unkown
HY-NP223 PLGF-2 Protein, human / Unkown
HY-P11647 RPARPAR Ligand / Unkown
HY-RS09205 NELL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09580 NRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17411 Nrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23865 Nrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992280 Anti-NRP2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrp2 NCBI NCBI:8828