Ntn1 - netrin 1 Gene

Also Known as Netrin-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18208

Summary

Predicted to be an extracellular matrix structural constituent. Involved in chemorepulsion of axon and regulation of synapse assembly. Acts upstream of or within several processes, including animal organ morphogenesis; generation of neurons; and nuclear migration. Located in basement membrane and cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; integumental system; lung; and sensory organ. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntn1 Products (1)

mRNA Protein Name
NM_008744.2 NP_032770.2 netrin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18585357 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axon guidance IMP
IMP: Inferred from mutant phenotype
18479186 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
12051827 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
10908620 MGI
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
10908620 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16481423 MGI
acts upstream of or within cell-cell adhesion IGI
IGI: Inferred from genetic interaction
16439476 MGI
involved in chemorepulsion of axon IDA
IDA: Inferred from direct assay
28483977 MGI
acts upstream of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
16481423 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
17616930 MGI
acts upstream of or within mammary gland development IGI
IGI: Inferred from genetic interaction
18425773 MGI
acts upstream of or within mammary gland duct morphogenesis IGI
IGI: Inferred from genetic interaction
16439476 MGI
acts upstream of or within motor neuron migration IMP
IMP: Inferred from mutant phenotype
16267219 MGI
acts upstream of or within negative regulation of axon extension IDA
IDA: Inferred from direct assay
10704383 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
14750959 MGI
acts upstream of or within nuclear migration IDA
IDA: Inferred from direct assay
12051827 MGI
acts upstream of or within positive regulation of axon extension IDA
IDA: Inferred from direct assay
10704383 MGI
acts upstream of or within positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
16481423 MGI
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
10704383 MGI
acts upstream of or within regulation of glial cell migration IMP
IMP: Inferred from mutant phenotype
16481423 MGI
involved in regulation of synapse assembly EXP
EXP: Inferred from Experiment
24174661 MGI
involved in regulation of synapse assembly IDA
IDA: Inferred from direct assay
24174661 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
24174661 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
18757743 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18425773 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24174661 MGI
is active in synapse IDA
IDA: Inferred from direct assay
24174661 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

netrin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09621 NTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18629 Ntn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25115 Ntn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntn1 NCBI NCBI:9423