NTN1 - netrin 1 Gene

Also Known as NET1; MRMV4; NTN1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9423

About NTN1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,003,087-9,244,000 (from NCBI)

This gene has 2 transcripts (splice variants), 270 orthologues, 27 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 20.8), esophagus (RPKM 16.8) and 17 other tissues.

Summary

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in Cancer development. [provided by RefSeq, Jul 2008]

NTN1 Products (1)

mRNA Protein Name
NM_004822.3 NP_004813.2 netrin-1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10102268 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
28945198 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTN1 Protein Structure

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (51 - 283)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (285 - 333)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (341 - 392)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (404 - 445)

NTR

NTR: UNC-6/NTR/C345C module (488 - 594)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 604 a.a.
Protein Preferred Names Protein Names

netrin-1

  • epididymis tissue protein Li 131P

NTN1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810962 Netrin 1 Antibody WB, IHC-P Human, Mouse
HY-P81897 Netrin 1 Antibody (YA1642) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Mirror Movements 4

  • MRMV4
Mirror Movements 1

  • Congenital Mirror Movement Disorder

  • Bimanual Synergia

  • Congenital Mirror Movements

  • Familial Congenital Controlateral Synkinesia

  • Familial Congenital Mirror Movements

  • Hereditary Congenital Controlateral Synkinesia

  • Hereditary Congenital Mirror Movements

  • Isolated Congenital Controlateral Synkinesia

  • Isolated Congenital Mirror Movements

  • Mirror Movements

  • MRMV1

  • Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum

  • Mirror Movements, Congenital

  • Bimanual Synkinesis

  • Cmm

  • Mirror Movements, Type 1
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Hydronephrosis

  • Stricture Of Ureteropelvic Junction With Hydronephrosis

  • Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Orofacial Cleft

  • Cleft, Orofacial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09621 NTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18629 Ntn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25115 Ntn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NTN1 VGNC VGNC:99313
Rattus norvegicus NTN1 RGD RGD:619809
Mus musculus NTN1 MGD MGI:105088
Bos taurus NTN1 VGNC VGNC:32304
Canis familiaris NTN1 VGNC VGNC:44007
Macaca mulatta NTN1 VGNC VGNC:104637
Others NTN1 NCBI