Netrin 1 Antibody
(Synonyms: NTN1L, NTN1, Netrin-1, Epididymis tissue protein Li 131P)Netrin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Netrin 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
Netrin 1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Netrin 1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 66 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 67 kDa
Synthetic peptide corresponding to the C-term region of human Netrin 1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Netrin 1 is a Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis[1][2].
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Subcellular Localization
Secreted; Cytoplasm
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Expression
Tissue_Specificity: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level). -
Isoforms & Post-Translational Modification
Netrin 1 has an amino acid length of 604, molecular weight is 67748 Da.
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Subunit
Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D.
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SwissProt ID
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Synonyms
NTN1L, NTN1, Netrin-1, Epididymis tissue protein Li 131P
Documentation
[1]. Shao Q, et al. Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. J Neurosci. 2017 Jun 7;37(23):5620-5633. [Content Brief]
[2]. Mazelin L, et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature. 2004 Sep 2;431(7004):80-4. [Content Brief]
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