Ntsr1 - neurotensin receptor 1 Gene

Also Known as NTR1; NT-1R; NTR-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18216

About Ntsr1

Chromosome 2: 180,141,769-180,186,773 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 213 orthologues, 14 paralogues and is associated with 16 phenotypes. Biased expression in CNS E18 (RPKM 4.6), genital fat pad adult (RPKM 1.5) and 1 other tissues.

Summary

Predicted to enable G protein-coupled Neurotensin Receptor activity; identical protein binding activity; and protein N-terminus binding activity. Acts upstream of or within adult locomotory behavior. Predicted to be located in several cellular components, including dendrite; perikaryon; and symmetric synapse. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; gallbladder; intestine; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human NTSR1 (Neurotensin Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntsr1 Products (1)

mRNA Protein Name
NM_018766.2 NP_061236.1 neurotensin receptor type 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult locomotory behavior IGI
IGI: Inferred from genetic interaction
15353215 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntsr1 Protein Structure

7tmA_NTSR1

7tmA_NTSR1: cd15355 (63 - 90)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (63 - 379)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (100 - 126)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (140 - 170)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (182 - 204)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (232 - 261)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (300 - 330)

7tmA_NTSR1

7tmA_NTSR1: cd15355 (347 - 372)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

neurotensin receptor type 1

  • NT-R-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125880 SBI-553 Modulator 99.73% Unkown
HY-164795A SBI-810 hydrochloride 99.55% Unkown
HY-164795 SBI-810 98.25% Unkown
HY-RS09638 NTSR1 Human Pre-designed siRNA Set A / Unkown
HY-153709 Zalsenertant tetraxetan Antagonist / Unkown
HY-182551 SR-12062 Agonist / Unkown
HY-P10698 VH-N412 / Unkown
HY-P11845 DOTA-NT-20.3-IPBA Modulator / Unkown
HY-RS09639 Ntsr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09640 Ntsr1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntsr1 NCBI NCBI:4923