NTSR1 - neurotensin receptor 1 Gene

Also Known as NTR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4923

About NTSR1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,708,836-62,762,771 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

Neurotensin Receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

NTSR1 Products (1)

mRNA Protein Name
NM_002531.3 NP_002522.2 neurotensin receptor type 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled neurotensin receptor activity IDA
IDA: Inferred from direct assay
21725197 GOA
enables G protein-coupled neurotensin receptor activity IMP
IMP: Inferred from mutant phenotype
8381365 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17620610 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17620610 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21725197 GOA
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
21725197 GOA
involved in neuropeptide signaling pathway IGI
IGI: Inferred from genetic interaction
21806946 GOA
acts upstream of positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
21806946 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane raft IDA
IDA: Inferred from direct assay
21725197 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
8381365 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTSR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (80 - 364)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

neurotensin receptor type 1

  • NT-R-1

  • NTR1

  • NTRH

  • high-affinity levocabastine-insensitive neurotensin receptor

  • neurotensin receptor 1 (high affinity)

NTSR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NTSR1 P30989 NTS Homo sapiens P30990
Light Scattering
17620610
Intra
NTSR1 P30989 NTSR1 Homo sapiens P30989
Light Scattering
17620610
Intra
NTSR1 P30989 NTSR1 Homo sapiens P30989
GMS
17620610
Intra
NTSR1 P30989 NTS Homo sapiens P30990
GMS
17620610
Intra
NTSR1 P30989 P30990-PRO_0000019524 Homo sapiens P30990-PRO_0000019524
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trigeminal Nerve Neoplasm

  • Neoplasm Of Trigeminal Nerve

  • Tumor Of Trigeminal Nerve
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Carcinoma Of Pancreas

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Cancer Of The Pancreas

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Brain Stem Medulloblastoma
Jugular Foramen Meningioma

  • Meningioma Of The Jugular Foramen
Acute Flaccid Myelitis
Paralytic Poliomyelitis

  • Poliomyelitis, Paralytic
Schwannoma Of Twelfth Cranial Nerve

  • Hypoglossal Schwannoma

  • Schwannoma Of The Twelfth Cranial Nerve
Suprasellar Meningioma
Hypoglossal Nerve Disease

  • Hypoglossal Nerve Diseases

  • Disorder Of 12th Nerve

  • Disorder Of Hypoglossal [12th] Nerve

  • Disorder Of Hypoglossal Nerve

  • Disorder Of Xii Nerve

  • Disorders Of The Twelfth Cranial Nerve

  • Disorders Of 12th Cranial Nerve
Petrous Apex Meningioma

  • Meningioma Of The Petrous Ridge
Neurilemmoma Of The Fifth Cranial Nerve

  • Trigeminal Schwannoma

  • Trigeminal Neurilemmoma
Colon Adenocarcinoma

  • Adenocarcinoma Of Colon

  • Adenocarcinoma Of The Colon

  • Colonic Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125880 SBI-553 Modulator 99.73% Unkown
HY-164795A SBI-810 hydrochloride 99.55% Unkown
HY-164795 SBI-810 98.25% Unkown
HY-RS09638 NTSR1 Human Pre-designed siRNA Set A / Unkown
HY-153709 Zalsenertant tetraxetan Antagonist / Unkown
HY-182551 SR-12062 Agonist / Unkown
HY-P10698 VH-N412 / Unkown
HY-P11845 DOTA-NT-20.3-IPBA Modulator / Unkown
HY-RS09639 Ntsr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09640 Ntsr1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NTSR1 RGD RGD:1306076
Canis familiaris NTSR1 VGNC VGNC:44014
Bos taurus NTSR1 VGNC VGNC:32312
Felis catus NTSR1 VGNC VGNC:68582
Mus musculus NTSR1 MGD MGI:97386
Macaca mulatta NTSR1 VGNC VGNC:75544
Others NTSR1 NCBI