TSC22D3 - TSC22 domain family member 3 Gene

Also Known as DIP; GILZ; DSIPI; TSC-22R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1831

About TSC22D3

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:107,713,221-107,777,086 (from NCBI)

This gene has 18 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 114.8), appendix (RPKM 102.3) and 25 other tissues.

Summary

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

TSC22D3 Products (5)

mRNA Protein Name
NM_001015881.2 NP_001015881.1 TSC22 domain family protein 3 isoform 3
NM_001318468.1 NP_001305397.1 TSC22 domain family protein 3 isoform 1
NM_001318470.1 NP_001305399.1 TSC22 domain family protein 3 isoform 1
NM_004089.4 NP_004080.2 TSC22 domain family protein 3 isoform 2
NM_198057.3 NP_932174.1 TSC22 domain family protein 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSC22D3 Protein Structure

TSC22

TSC22: TSC-22/dip/bun family (58 - 116)

  • 0
  • 100
  • 134 a.a.
Protein Preferred Names Protein Names

TSC22 domain family protein 3

  • DSIP-immunoreactive leucine zipper protein

TSC22D3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSC22D3 Q99576 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
TSC22D3 Q99576 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
TSC22D3 Q99576 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra
TSC22D3 Q99576 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra
TSC22D3 Q99576 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Atrophy

  • Atrophic Condition Of Skin

  • Atrophoderma

  • Atrophy - Skin
Major Depressive Disorder

  • Seasonal Affective Disorder

  • Unipolar Depression

  • Depression

  • MDD

  • Depressive Disorder

  • Unipolar Depression, Susceptibility To

  • Major Depressive Disorder 1

  • Major Depressive Disorder, Response To Citalopram Therapy In

  • Major Depressive Disorder 2

  • Winter Depression

  • Single Major Depressive Episode

  • Sad

  • Clinical Depression

  • Major Depression

  • Depressive Syndrome

  • Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

  • Seasonal Affective Disorder, Susceptibility To

  • Recurrent Major Depression

  • Affective Disorder, Seasonal

  • Depression In A Seasonal Pattern

  • Depression

  • Seasonal

  • Major Depressive Disorder With A Seasonal Pattern

  • Seasonal Depression

  • Seasonal Mood Disorder

  • Mental Depression

  • Recurrent Major Depressive Episodes
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15135 TSC22D3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22051 Tsc22d3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TSC22D3 MGD MGI:1196284
Canis familiaris TSC22D3 VGNC VGNC:54608
Rattus norvegicus TSC22D3 RGD RGD:621654
Felis catus TSC22D3 VGNC VGNC:103756
Others TSC22D3 NCBI