Sigmar1 - sigma non-opioid intracellular receptor 1 Gene

Also Known as Oprs1; Sig1R; sigma1R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18391

About Sigmar1

Chromosome 4: 41,738,493-41,756,157 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 206 orthologues and is associated with 7 phenotypes. Ubiquitous expression in liver adult (RPKM 37.), subcutaneous fat pad adult (RPKM 22.3) and 28 other tissues.

Summary

This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]

Sigmar1 Products (8)

mRNA Protein Name
NM_001286539.1 NP_001273468.1 sigma non-opioid intracellular receptor 1 isoform 3
NM_001286540.1 NP_001273469.1 sigma non-opioid intracellular receptor 1 isoform 4
NM_011014.3 NP_035144.1 sigma non-opioid intracellular receptor 1 isoform 1
NM_001286605.1 NP_001273534.1 sigma non-opioid intracellular receptor 1 isoform 7
NM_001286551.1 NP_001273480.1 sigma non-opioid intracellular receptor 1 isoform 7
NM_001286538.1 NP_001273467.1 sigma non-opioid intracellular receptor 1 isoform 2
NM_001286541.1 NP_001273470.1 sigma non-opioid intracellular receptor 1 isoform 5
NM_001286542.1 NP_001273471.1 sigma non-opioid intracellular receptor 1 isoform 6

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17981125 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
14622179 MGI
Cellular Component GO Annotation Evidence References Source
is active in postsynapse IDA
IDA: Inferred from direct assay
20167253 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
20167253 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sigmar1 Protein Structure

ERG2_Sigma1R

ERG2_Sigma1R: pfam04622 (26 - 213)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

sigma non-opioid intracellular receptor 1

  • opioid receptor, sigma 1

  • sigma 1 receptor variant SR-1D

  • sigma 1-type opioid receptor

  • sigma1-receptor

Sigmar1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sigmar1 O55242 Kcna2 Mus musculus P63141
Confocal
23332758
Intra
Sigmar1 O55242 Kcna2 Mus musculus P63141
Crosslink
23332758
Cross
Sigmar1 O55242 HSPA5 Cricetulus griseus G3I8R9
Immunodepletion CoIP
17981125
Cross
Sigmar1 O55242 HSPA5 Cricetulus griseus G3I8R9
Anti Bait CoIP
17981125
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0837 Veratramine 99.88% Unkown
HY-RS12909 Sigmar1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS12910 Sigmar1 Rat Pre-designed siRNA Set A / Unkown
HY-RS12908 SIGMAR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sigmar1 NCBI NCBI:10280