Oxtr - oxytocin receptor Gene

Also Known as OTR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18430

About Oxtr

Chromosome 6: 112,450,644-112,466,904 reverse strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 265 orthologues, 16 paralogues and is associated with 14 phenotypes. Biased expression in adrenal adult (RPKM 71.9), mammary gland adult (RPKM 22.4) and 3 other tissues.

Summary

Predicted to enable Oxytocin Receptor activity; peptide hormone binding activity; and Vasopressin Receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of blood pressure. Predicted to be located in adherens junction; apical plasma membrane; and microvillus. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adipose tissue; brain; genitourinary system; integumental system; and small intestine. Orthologous to human OXTR (Oxytocin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Oxtr Products (2)

mRNA Protein Name
NM_001081147.3 NP_001074616.1 oxytocin receptor isoform 1
NM_001410246.1 NP_001397175.1 oxytocin receptor isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of blood pressure IGI
IGI: Inferred from genetic interaction
12486173 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24002032 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Oxtr Protein Structure

7tmA_OT_R

7tmA_OT_R: cd15387 (39 - 338)

7tmA_OT_R

7tmA_OT_R: cd15387 (40 - 66)

7tmA_OT_R

7tmA_OT_R: cd15387 (73 - 100)

7tmA_OT_R

7tmA_OT_R: cd15387 (111 - 141)

7tmA_OT_R

7tmA_OT_R: cd15387 (151 - 172)

7tmA_OT_R

7tmA_OT_R: cd15387 (196 - 225)

7tmA_OT_R

7tmA_OT_R: cd15387 (266 - 296)

7tmA_OT_R

7tmA_OT_R: cd15387 (306 - 331)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

oxytocin receptor

  • OT-R

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108678 TC OT 39 97.70% Unkown
HY-P4990 Pro8-Oxytocin Activator 99.68% Unkown
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% Unkown
HY-P5017 (Val3,Pro8)-Oxytocin Agonist / Unkown
HY-RS09894 OXTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09895 Oxtr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09896 Oxtr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180870 OXTR modulator-1 / Unkown
HY-180870A OXTR modulator-2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Oxtr NCBI NCBI:5021