Pabpc1 - poly(A) binding protein, cytoplasmic 1 Gene

Also Known as PABP; ePAB; Pabp1; PabpI; Pabpl1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18458

Summary

Predicted to enable RNA binding activity and protein C-terminus binding activity. Involved in gene silencing by RNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm and synapse. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1). [provided by Alliance of Genome Resources, Apr 2022]

Pabpc1 Products (1)

mRNA Protein Name
NM_008774.3 NP_032800.2 polyadenylate-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17927953 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
IMP: Inferred from mutant phenotype
19716330 MGI
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
IMP: Inferred from mutant phenotype
19716330 MGI
involved in regulatory ncRNA-mediated gene silencing IMP
IMP: Inferred from mutant phenotype
19716330 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18625844 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyadenylate-binding protein 1

  • PABP-1

  • poly(A)-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09948 PABPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19518 Pabpc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26013 Pabpc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990727 Alextatug / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pabpc1 NCBI NCBI:26986