Pax1 - paired box 1 Gene

Also Known as un; wt; hbs; Pax-1; hunchback; undulated

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18503

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development; cell population proliferation; and somitogenesis. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in several structures, including branchial pouch; central nervous system; embryo mesenchyme; limb; and musculoskeletal system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome. Orthologous to human PAX1 (paired box 1). [provided by Alliance of Genome Resources, Apr 2022]

Pax1 Products (1)

mRNA	Protein	Name
NM_008780.2	NP_032806.2	paired box protein Pax-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12490554	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12490554	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	12490554	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	16093716	MGI
acts upstream of or within CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	16093716	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	7607069	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	10364424	MGI
acts upstream of or within parathyroid gland development	IGI IGI: Inferred from genetic interaction	11476574	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	11900462	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12490554	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15024065	MGI
involved in sclerotome development	IEP IEP: Inferred from expression pattern	7743923	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	10364424	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	10364424	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	16093716	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	11476574	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
paired box protein Pax-1	paired box gene 1 wavy tail

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10088	PAX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122585	proMMP-9 inhibitor-3c	Inhibitor	/	Unkown
HY-174562	Human PAX1 mRNA		/	Unkown
HY-RS22267	Pax1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28790	Pax1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax1	NCBI	NCBI:5075