Pcsk2 - proprotein convertase subtilisin/kexin type 2 Gene

Also Known as PC2; Nec2; SPC2; Nec-2; Phpp-2; 6330411F23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18549

Summary

Enables serine-type endopeptidase activity. Involved in enkephalin processing and protein autoprocessing. Acts upstream of or within nervous system development and proteolysis. Located in extracellular space. Is expressed in brain; endocrine gland; future brain; and gut. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk2 Products (1)

mRNA Protein Name
NM_008792.4 NP_032818.1 neuroendocrine convertase 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
9242664 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
8262946 MGI
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
9452465 MGI
Biological Process GO Annotation Evidence References Source
involved in enkephalin processing IDA
IDA: Inferred from direct assay
8262946 MGI
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
9452465 MGI
involved in nervous system development IEP
IEP: Inferred from expression pattern
16893422 MGI
involved in peptide hormone processing IDA
IDA: Inferred from direct assay
9242664 MGI
acts upstream of or within peptide hormone processing IMP
IMP: Inferred from mutant phenotype
12859669 MGI
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
16893422 MGI
involved in protein processing IDA
IDA: Inferred from direct assay
9242664 MGI
acts upstream of or within proteolysis IMP
IMP: Inferred from mutant phenotype
12859669 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8397508 MGI
is active in secretory granule IDA
IDA: Inferred from direct assay
9452465 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroendocrine convertase 2

  • KEX2-like endoprotease 2

  • NEC 2

  • prohormone convertase 2

  • proprotein convertase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10172 PCSK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21016 Pcsk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27533 Pcsk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk2 NCBI NCBI:5126