Pdpk1 - 3-phosphoinositide dependent protein kinase 1 Gene

Also Known as Pdk1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18607

Summary

Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; regulation of mast cell degranulation; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdpk1 Products (3)

mRNA	Protein	Name
NM_001080773.2	NP_001074242.1	3-phosphoinositide-dependent protein kinase 1 isoform B
NM_001286662.1	NP_001273591.1	3-phosphoinositide-dependent protein kinase 1 isoform C
NM_011062.4	NP_035192.2	3-phosphoinositide-dependent protein kinase 1 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3-phosphoinositide-dependent protein kinase activity	IDA IDA: Inferred from direct assay	10075713	MGI
enables 3-phosphoinositide-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	15116068	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16337591	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within hyperosmotic response	IDA IDA: Inferred from direct assay	12783890	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	19047061	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18347057	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	23472139	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	33377210	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19429709	MGI
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20584979	MGI
involved in regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17371830	MGI
involved in regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	21063107	MGI
involved in type B pancreatic cell development	IMP IMP: Inferred from mutant phenotype	19635472	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12783890	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12783890	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
3-phosphoinositide-dependent protein kinase 1	Pkb kinase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12063	PHT-427		98.09%	Unkown
HY-123467	Lasiokaurin		99.68%	Unkown
HY-N1022	11-Hydroxytephrosin	Inhibitor	≥98.0%	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-RS10287	PDPK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W719359	PHT-427-d4		/	Unkown
HY-N11231	Fucoxanthinol		/	Unkown
HY-RS17027	Pdpk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23470	Pdpk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdpk1	NCBI	NCBI:5170